Literature DB >> 34167916

Ether phospholipids govern ferroptosis.

Hyemin Lee1, Li Zhuang1, Boyi Gan2.   

Abstract

Ferroptosis is a cell death modality triggered by excessive lipid peroxidation. Two recent studies (Zou et al., 2020; Cui et al., 2021) not only reveal critical roles of ether-linked phospholipids as an additional source for providing polyunsaturated fatty acid-containing phospholipids in driving ferroptosis but also suggest a context-dependent role of TMEM189-mediated vinyl-ether phospholipid (plasmalogen) synthesis in ferroptosis.
Copyright © 2021 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Ether phospholipids; Ferroptosis; Lipid peroxidation; Plasmalogen; TMEM189

Mesh：

Year:  2021        PMID： 34167916      PMCID： PMC8453040          DOI： 10.1016/j.jgg.2021.05.003

Source DB:  PubMed          Journal:  J Genet Genomics        ISSN： 1673-8527            Impact factor:   5.723


  10 in total

1.  A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis.

Authors:  Aránzazu Gallego-García; Antonio J Monera-Girona; Elena Pajares-Martínez; Eva Bastida-Martínez; Ricardo Pérez-Castaño; Antonio A Iniesta; Marta Fontes; S Padmanabhan; Montserrat Elías-Arnanz
Journal:  Science       Date:  2019-10-04       Impact factor: 47.728

2.  Ferroptosis: an iron-dependent form of nonapoptotic cell death.

Authors:  Scott J Dixon; Kathryn M Lemberg; Michael R Lamprecht; Rachid Skouta; Eleina M Zaitsev; Caroline E Gleason; Darpan N Patel; Andras J Bauer; Alexandra M Cantley; Wan Seok Yang; Barclay Morrison; Brent R Stockwell
Journal:  Cell       Date:  2012-05-25       Impact factor: 41.582

3.  Regulation of ferroptotic cancer cell death by GPX4.

Authors:  Wan Seok Yang; Rohitha SriRamaratnam; Matthew E Welsch; Kenichi Shimada; Rachid Skouta; Vasanthi S Viswanathan; Jaime H Cheah; Paul A Clemons; Alykhan F Shamji; Clary B Clish; Lewis M Brown; Albert W Girotti; Virginia W Cornish; Stuart L Schreiber; Brent R Stockwell
Journal:  Cell       Date:  2014-01-16       Impact factor: 41.582

4.  Plasticity of ether lipids promotes ferroptosis susceptibility and evasion.

Authors:  Yilong Zou; Whitney S Henry; Emily L Ricq; Emily T Graham; Vaishnavi V Phadnis; Pema Maretich; Sateja Paradkar; Natalie Boehnke; Amy A Deik; Ferenc Reinhardt; John K Eaton; Bryan Ferguson; Wenyu Wang; Joshua Fairman; Heather R Keys; Vlado Dančík; Clary B Clish; Paul A Clemons; Paula T Hammond; Laurie A Boyer; Robert A Weinberg; Stuart L Schreiber
Journal:  Nature       Date:  2020-09-16       Impact factor: 49.962

Review 5.  Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

Authors:  Brent R Stockwell; José Pedro Friedmann Angeli; Hülya Bayir; Ashley I Bush; Marcus Conrad; Scott J Dixon; Simone Fulda; Sergio Gascón; Stavroula K Hatzios; Valerian E Kagan; Kay Noel; Xuejun Jiang; Andreas Linkermann; Maureen E Murphy; Michael Overholtzer; Atsushi Oyagi; Gabriela C Pagnussat; Jason Park; Qitao Ran; Craig S Rosenfeld; Konstantin Salnikow; Daolin Tang; Frank M Torti; Suzy V Torti; Shinya Toyokuni; K A Woerpel; Donna D Zhang
Journal:  Cell       Date:  2017-10-05       Impact factor: 41.582

6.  Dietary Lipids Induce Ferroptosis in Caenorhabditiselegans and Human Cancer Cells.

Authors:  Marcos A Perez; Leslie Magtanong; Scott J Dixon; Jennifer L Watts
Journal:  Dev Cell       Date:  2020-07-10       Impact factor: 12.270

Review 7.  Structural and functional roles of ether lipids.

Authors:  John M Dean; Irfan J Lodhi
Journal:  Protein Cell       Date:  2017-05-18       Impact factor: 14.870

8.  Energy-stress-mediated AMPK activation inhibits ferroptosis.

Authors:  Hyemin Lee; Fereshteh Zandkarimi; Yilei Zhang; Jitendra Kumar Meena; Jongchan Kim; Li Zhuang; Siddhartha Tyagi; Li Ma; Thomas F Westbrook; Gregory R Steinberg; Daisuke Nakada; Brent R Stockwell; Boyi Gan
Journal:  Nat Cell Biol       Date:  2020-02-06       Impact factor: 28.824

9.  Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis.

Authors:  Weiwei Cui; Dong Liu; Wei Gu; Bo Chu
Journal:  Cell Death Differ       Date:  2021-03-17       Impact factor: 15.828

10.  The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens.

Authors:  Ernst R Werner; Markus A Keller; Sabrina Sailer; Katharina Lackner; Jakob Koch; Martin Hermann; Stefan Coassin; Georg Golderer; Gabriele Werner-Felmayer; Raphael A Zoeller; Nicolas Hulo; Johannes Berger; Katrin Watschinger
Journal:  Proc Natl Acad Sci U S A       Date:  2020-03-24       Impact factor: 12.779
  10 in total
  2 in total

Review 1.  Targeting ferroptosis as a vulnerability in cancer.

Authors:  Guang Lei; Li Zhuang; Boyi Gan
Journal:  Nat Rev Cancer       Date:  2022-03-25       Impact factor: 69.800

Review 2.  Ferroptosis: Redox Imbalance and Hematological Tumorigenesis.

Authors:  Hongying Lan; Yu Gao; Zhengyang Zhao; Ziqing Mei; Feng Wang
Journal:  Front Oncol       Date:  2022-01-26       Impact factor: 6.244
  2 in total

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