Tao Xue1, Kejing Yan2, Yiqi Cai3, Jiancheng Sun3, Zhejing Chen3, Xiaolei Chen3, Wenyi Wu4. 1. Department of Traumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, China. 2. Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang Province, China. 3. Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, No. 1 West Fanhai Road, Ouhai District, Wenzhou, 325000, Zhejiang Province, China. 4. Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, No. 1 West Fanhai Road, Ouhai District, Wenzhou, 325000, Zhejiang Province, China. wuwenyi2021@163.com.
Abstract
BACKGROUND: This study aimed to explore the prognostic significance of tumor-associated macrophage (TAM) infiltration in colorectal cancer (CRC) patients. METHODS: Tissue microarray and immunohistochemistry were used to detect the infiltration of CD163+ TAMs in 209 CRC samples, and the Kaplan-Meier method was used for survival analysis. Cox proportional hazards analysis was used for univariate analysis and multivariate analysis of clinically relevant confounders. RESULTS: The samples were divided into low-level (n = 105) and high-level infiltration groups (n = 104) by the median number of CD163+ TAMs detected. The overall survival (OS) and disease-free survival (DFS) of CRC patients in the low-level CD163+ TAM infiltration group were longer than those in the high-level CD163+ TAM infiltration group (P < 0.001). Infiltration of CD163+ TAMs in CRC tissues was a negative prognostic factor for CRC patients. Risks of death and disease recurrence for CRC patients in the low-level CD163+ TAM infiltration group were lower than those in the high-level CD163+ TAM infiltration group (HROS = 0.183, 95% CI 0.052-0.647, P = 0.008; HRDFS = 0.191, 95% CI 0.078-0.470, P = 0.000). CONCLUSIONS: The infiltration of CD163+ TAMs in CRC tissue is an independent adverse factor for the prognosis of CRC patients. High-level infiltration of CD163+ TAMs is associated with shorter OS and DFS.
BACKGROUND: This study aimed to explore the prognostic significance of tumor-associated macrophage (TAM) infiltration in colorectal cancer (CRC) patients. METHODS: Tissue microarray and immunohistochemistry were used to detect the infiltration of CD163+ TAMs in 209 CRC samples, and the Kaplan-Meier method was used for survival analysis. Cox proportional hazards analysis was used for univariate analysis and multivariate analysis of clinically relevant confounders. RESULTS: The samples were divided into low-level (n = 105) and high-level infiltration groups (n = 104) by the median number of CD163+ TAMs detected. The overall survival (OS) and disease-free survival (DFS) of CRCpatients in the low-level CD163+ TAM infiltration group were longer than those in the high-level CD163+ TAM infiltration group (P < 0.001). Infiltration of CD163+ TAMs in CRC tissues was a negative prognostic factor for CRCpatients. Risks of death and disease recurrence for CRCpatients in the low-level CD163+ TAM infiltration group were lower than those in the high-level CD163+ TAM infiltration group (HROS = 0.183, 95% CI 0.052-0.647, P = 0.008; HRDFS = 0.191, 95% CI 0.078-0.470, P = 0.000). CONCLUSIONS: The infiltration of CD163+ TAMs in CRC tissue is an independent adverse factor for the prognosis of CRCpatients. High-level infiltration of CD163+ TAMs is associated with shorter OS and DFS.
Authors: Luca Noti; José A Galván; Heather Dawson; Alessandro Lugli; Richard Kirsch; Naziheh Assarzadegan; David Messenger; Philippe Krebs; Martin D Berger; Inti Zlobec Journal: BMC Cancer Date: 2022-09-16 Impact factor: 4.638