Literature DB >> 34165722

Strategies to Study the Functions of Pseudogenes in Mouse Models of Cancer.

Ilah Bok1,2, Florian A Karreth3.   

Abstract

Aberrant expression of pseudogenes has been observed in many cancer types. Deregulated pseudogenes engage in a multitude of biological processes at the DNA, RNA, and protein levels and eventually facilitate disease progression. To investigate pseudogene functions in cancer, cell lines and cell line transplantation models have been widely used. However, cancer biology is best studied in the context of an intact organism. Here, we present various strategies to investigate pseudogenes in genetically engineered mouse models and discuss advantages and disadvantages of the different approaches.

Entities:  

Keywords:  Cancer; ESC-GEMM; Genetically engineered mouse model; Pseudogene

Year:  2021        PMID： 34165722     DOI： 10.1007/978-1-0716-1503-4_18

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  46 in total

1.  An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene.

Authors:  Shinji Hirotsune; Noriyuki Yoshida; Amy Chen; Lisa Garrett; Fumihiro Sugiyama; Satoru Takahashi; Ken-ichi Yagami; Anthony Wynshaw-Boris; Atsushi Yoshiki
Journal:  Nature       Date:  2003-05-01       Impact factor: 49.962

2.  Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes.

Authors:  Oliver H Tam; Alexei A Aravin; Paula Stein; Angelique Girard; Elizabeth P Murchison; Sihem Cheloufi; Emily Hodges; Martin Anger; Ravi Sachidanandam; Richard M Schultz; Gregory J Hannon
Journal:  Nature       Date:  2008-04-10       Impact factor: 49.962

3.  Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes.

Authors:  Toshiaki Watanabe; Yasushi Totoki; Atsushi Toyoda; Masahiro Kaneda; Satomi Kuramochi-Miyagawa; Yayoi Obata; Hatsune Chiba; Yuji Kohara; Tomohiro Kono; Toru Nakano; M Azim Surani; Yoshiyuki Sakaki; Hiroyuki Sasaki
Journal:  Nature       Date:  2008-04-10       Impact factor: 49.962

4.  Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.

Authors:  Cécile Charrier; Kaumudi Joshi; Jaeda Coutinho-Budd; Ji-Eun Kim; Nelle Lambert; Jacqueline de Marchena; Wei-Lin Jin; Pierre Vanderhaeghen; Anirvan Ghosh; Takayuki Sassa; Franck Polleux
Journal:  Cell       Date:  2012-05-03       Impact factor: 41.582

5.  Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene.

Authors:  J R McCarrey; K Thomas
Journal:  Nature       Date:  1987 Apr 2-8       Impact factor: 49.962

Review 6.  Overcoming challenges and dogmas to understand the functions of pseudogenes.

Authors:  Seth W Cheetham; Geoffrey J Faulkner; Marcel E Dinger
Journal:  Nat Rev Genet       Date:  2019-12-17       Impact factor: 53.242

7.  Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis.

Authors:  Ian T Fiddes; Gerrald A Lodewijk; Meghan Mooring; Colleen M Bosworth; Adam D Ewing; Gary L Mantalas; Adam M Novak; Anouk van den Bout; Alex Bishara; Jimi L Rosenkrantz; Ryan Lorig-Roach; Andrew R Field; Maximilian Haeussler; Lotte Russo; Aparna Bhaduri; Tomasz J Nowakowski; Alex A Pollen; Max L Dougherty; Xander Nuttle; Marie-Claude Addor; Simon Zwolinski; Sol Katzman; Arnold Kriegstein; Evan E Eichler; Sofie R Salama; Frank M J Jacobs; David Haussler
Journal:  Cell       Date:  2018-05-31       Impact factor: 41.582

8.  Transcribed processed pseudogenes in the human genome: an intermediate form of expressed retrosequence lacking protein-coding ability.

Authors:  Paul M Harrison; Deyou Zheng; Zhaolei Zhang; Nicholas Carriero; Mark Gerstein
Journal:  Nucleic Acids Res       Date:  2005-04-28       Impact factor: 16.971

9.  Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation.

Authors:  Ikuo K Suzuki; David Gacquer; Roxane Van Heurck; Devesh Kumar; Marta Wojno; Angéline Bilheu; Adèle Herpoel; Nelle Lambert; Julian Cheron; Franck Polleux; Vincent Detours; Pierre Vanderhaeghen
Journal:  Cell       Date:  2018-05-31       Impact factor: 41.582

10.  A draft map of the human proteome.

Authors:  Min-Sik Kim; Sneha M Pinto; Derese Getnet; Raja Sekhar Nirujogi; Srikanth S Manda; Raghothama Chaerkady; Anil K Madugundu; Dhanashree S Kelkar; Ruth Isserlin; Shobhit Jain; Joji K Thomas; Babylakshmi Muthusamy; Pamela Leal-Rojas; Praveen Kumar; Nandini A Sahasrabuddhe; Lavanya Balakrishnan; Jayshree Advani; Bijesh George; Santosh Renuse; Lakshmi Dhevi N Selvan; Arun H Patil; Vishalakshi Nanjappa; Aneesha Radhakrishnan; Samarjeet Prasad; Tejaswini Subbannayya; Rajesh Raju; Manish Kumar; Sreelakshmi K Sreenivasamurthy; Arivusudar Marimuthu; Gajanan J Sathe; Sandip Chavan; Keshava K Datta; Yashwanth Subbannayya; Apeksha Sahu; Soujanya D Yelamanchi; Savita Jayaram; Pavithra Rajagopalan; Jyoti Sharma; Krishna R Murthy; Nazia Syed; Renu Goel; Aafaque A Khan; Sartaj Ahmad; Gourav Dey; Keshav Mudgal; Aditi Chatterjee; Tai-Chung Huang; Jun Zhong; Xinyan Wu; Patrick G Shaw; Donald Freed; Muhammad S Zahari; Kanchan K Mukherjee; Subramanian Shankar; Anita Mahadevan; Henry Lam; Christopher J Mitchell; Susarla Krishna Shankar; Parthasarathy Satishchandra; John T Schroeder; Ravi Sirdeshmukh; Anirban Maitra; Steven D Leach; Charles G Drake; Marc K Halushka; T S Keshava Prasad; Ralph H Hruban; Candace L Kerr; Gary D Bader; Christine A Iacobuzio-Donahue; Harsha Gowda; Akhilesh Pandey
Journal:  Nature       Date:  2014-05-29       Impact factor: 49.962
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  1 in total

Review 1.  Virtual Gene Concept and a Corresponding Pragmatic Research Program in Genetical Data Science.

Authors:  Łukasz Huminiecki
Journal:  Entropy (Basel)       Date:  2021-12-23       Impact factor: 2.524
  1 in total

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