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Literature DB >> 34165712

Pseudogenes as Competitive Endogenous RNAs: Target Prediction and Validation.

Florian A Karreth¹, Ugo Ala², Paolo Provero^3,4, Pier Paolo Pandolfi^5,6.

Abstract

Pseudogenes may regulate expression of their parental genes as well as other protein-coding genes through various mechanisms. One such mechanism is the ability to act as competitive endogenous RNA (ceRNA) and participate in microRNA-mediated cross-regulation. Here, we outline how to predict the targets of pseudogene ceRNAs bioinformatically and how to validate them experimentally.

Entities: Chemical

Keywords: 3′UTR; Prediction; Pseudogene; Validation; ceRNA

Mesh：

Substances：

Year: 2021 PMID： 34165712 DOI： 10.1007/978-1-0716-1503-4_8

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

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References

27 in total

1. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs.

Authors: Yvonne Tay; Lev Kats; Leonardo Salmena; Dror Weiss; Shen Mynn Tan; Ugo Ala; Florian Karreth; Laura Poliseno; Paolo Provero; Ferdinando Di Cunto; Judy Lieberman; Isidore Rigoutsos; Pier Paolo Pandolfi
Journal: Cell Date: 2011-10-14 Impact factor: 41.582

2. In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma.

Authors: Florian A Karreth; Yvonne Tay; Daniele Perna; Ugo Ala; Shen Mynn Tan; Alistair G Rust; Gina DeNicola; Kaitlyn A Webster; Dror Weiss; Pedro A Perez-Mancera; Michael Krauthammer; Ruth Halaban; Paolo Provero; David J Adams; David A Tuveson; Pier Paolo Pandolfi
Journal: Cell Date: 2011-10-14 Impact factor: 41.582

3. An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma.

Authors: Pavel Sumazin; Xuerui Yang; Hua-Sheng Chiu; Wei-Jen Chung; Archana Iyer; David Llobet-Navas; Presha Rajbhandari; Mukesh Bansal; Paolo Guarnieri; Jose Silva; Andrea Califano
Journal: Cell Date: 2011-10-14 Impact factor: 41.582

Pseudogenes as Competitive Endogenous RNAs: Target Prediction and Validation.

1. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs.

2. In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma.

3. An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma.

Review 4. Pseudogenes: newly discovered players in human cancer.

5. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?

Review 6. ceRNA cross-talk in cancer: when ce-bling rivalries go awry.

7. Target mimicry provides a new mechanism for regulation of microRNA activity.

8. Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA.

9. A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA.

10. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology.