Akiko Yashima-Abo1, Koki Otsuka2, Satoshi S Nishizuka3. 1. Division of Biomedical Research and Development, Iwate Medical University Institute for Biomedical Sciences, Yahaba, Iwate, Japan. 2. Department of Surgery, Iwate Medical University School of Medicine, Yahaba, Iwate, Japan. 3. Division of Biomedical Research and Development, Iwate Medical University Institute for Biomedical Sciences, Yahaba, Iwate, Japan. snishizu@iwate-med.ac.jp.