| Literature DB >> 34163090 |
Rebecca Jane Cox1,2, Nina Langeland3,4,5, Bjørn Blomberg6,7,8, Kristin Greve-Isdahl Mohn9,10, Karl Albert Brokstad11,12, Fan Zhou10, Dagrun Waag Linchausen13, Bent-Are Hansen14, Sarah Lartey10, Therese Bredholt Onyango10, Kanika Kuwelker15,16,9,10, Marianne Sævik9, Hauke Bartsch17,18, Camilla Tøndel19,20, Bård Reiakvam Kittang15,14.
Abstract
Long-term complications after coronavirus disease 2019 (COVID-19) are common in hospitalized patients, but the spectrum of symptoms in milder cases needs further investigation. We conducted a long-term follow-up in a prospective cohort study of 312 patients-247 home-isolated and 65 hospitalized-comprising 82% of total cases in Bergen during the first pandemic wave in Norway. At 6 months, 61% (189/312) of all patients had persistent symptoms, which were independently associated with severity of initial illness, increased convalescent antibody titers and pre-existing chronic lung disease. We found that 52% (32/61) of home-isolated young adults, aged 16-30 years, had symptoms at 6 months, including loss of taste and/or smell (28%, 17/61), fatigue (21%, 13/61), dyspnea (13%, 8/61), impaired concentration (13%, 8/61) and memory problems (11%, 7/61). Our findings that young, home-isolated adults with mild COVID-19 are at risk of long-lasting dyspnea and cognitive symptoms highlight the importance of infection control measures, such as vaccination.Entities:
Year: 2021 PMID： 34163090 DOI： 10.1038/s41591-021-01433-3
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440