Literature DB >> 34161948

Aging and Mesenchymal Stem Cells: Therapeutic Opportunities and Challenges in the Older Group.

Huan Chen1, Ousheng Liu1, Sijia Chen1, Yueying Zhou1.   

Abstract

With aging, a portion of cells, including mesenchymal stem cells (MSCs), become senescent, and these senescent cells accumulate and promote various age-related diseases. Therefore, the older age group has become a major population for MSC therapy, which is aimed at improving tissue regeneration and function of the aged body. However, the application of MSC therapy is often unsatisfying in the aged group. One reasonable conjecture for this correlation is that aging microenvironment reduces the number and function of MSCs. Cellular senescence also plays an important role in MSC function impairment. Thus, it is necessary to explore the relationship between senescence and MSCs for improving the application of MSCs in the elderly. Here, we present the influence of aging on MSCs and the characteristics and functional changes of senescent MSCs. Furthermore, current therapeutic strategies for improving MSC therapy in the elderly group are also discussed.
© 2021 The Author(s) Published by S. Karger AG, Basel.

Entities:  

Keywords:  Aged group; Antiaging; Cellular senescence; Mesenchymal stem cell therapy; Mesenchymal stem cells

Mesh：

Year:  2021        PMID： 34161948      PMCID： PMC8985028          DOI： 10.1159/000516668

Source DB:  PubMed          Journal:  Gerontology        ISSN： 0304-324X            Impact factor:   5.140


  198 in total

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5.  Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway.

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Review 9.  Cellular senescence in oral cancer and precancer and treatment implications: a review.

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