Mohammed A Kyyaly1,2,3, Tilman Sanchez-Elsner2,3, Peijun He4, Collin L Sones4, S Hasan Arshad1,2,3, Ramesh J Kurukulaaratchy1,2,3. 1. David Hide Asthma and Allergy Research Centre, Newport, Isle of Wight, UK. 2. School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. 3. Respiratory Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, UK. 4. Optoelectronics Research Centre, University of Southampton, Southampton, UK.
Abstract
BACKGROUND: Identifying patients at risk of severe asthma is vitally important given the disproportionate burden of disease imposed by that state. However, biomarkers to support such needs remain elusive. METHODS: In this letter, we assessed whether specific panels of circulating miRNAs (microRNAs) can differentiate between mild and severe asthma patients as well as between healthy subjects and severe asthma patients. RESULTS: To our knowledge, the miRNAs identified in our work such as miR-28-3p, miR-16-2-3p, and miR-210-3p have not been previously reported as differentially expressed in the serum of severe asthma patients. CONCLUSION: Our findings suggest that miRNA expression profiles may have the capability as potential biomarkers that signal the risk of having severe asthma. As such, these findings have significant novelty and merit wider dissemination to facilitate further work in this field.
BACKGROUND: Identifying patients at risk of severe asthma is vitally important given the disproportionate burden of disease imposed by that state. However, biomarkers to support such needs remain elusive. METHODS: In this letter, we assessed whether specific panels of circulating miRNAs (microRNAs) can differentiate between mild and severe asthmapatients as well as between healthy subjects and severe asthmapatients. RESULTS: To our knowledge, the miRNAs identified in our work such as miR-28-3p, miR-16-2-3p, and miR-210-3p have not been previously reported as differentially expressed in the serum of severe asthmapatients. CONCLUSION: Our findings suggest that miRNA expression profiles may have the capability as potential biomarkers that signal the risk of having severe asthma. As such, these findings have significant novelty and merit wider dissemination to facilitate further work in this field.
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