Literature DB >> 34161223

Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland.

Maureen Lynch, Guerrino Macori, Séamus Fanning, Edel O'Regan, Eoin Hunt, Dermot O'Callaghan, Brian McCullagh, Cormac Jennings, Anne Fortune.   

Abstract

We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged infection in immunocompromised patients may lead to emergence of new virus variants.

Entities:  

Keywords:  2019 novel coronavirus disease; B-cell therapy; COVID-19; SARS-CoV-2; coronavirus disease; immunocompromised; respiratory infections; severe acute respiratory syndrome coronavirus 2; superinfection; virus evolution; viruses; zoonoses

Year:  2021        PMID： 34161223     DOI： 10.3201/eid2709.211159

Source DB:  PubMed          Journal:  Emerg Infect Dis        ISSN： 1080-6040            Impact factor:   6.883


  6 in total

1.  Evaluation of In-Hospital Cluster of COVID-19 Associated With a Patient With Prolonged Viral Shedding Using Whole-Genome Sequencing.

Authors:  Jiwon Jung; Jungmin Lee; Sun-Kyung Kim; Soyeon Park; Young-Ju Lim; Eun Ok Kim; Heedo Park; Man-Seong Park; Sung-Han Kim
Journal:  J Korean Med Sci       Date:  2022-10-10       Impact factor: 5.354

Review 2.  Identifying Markers of Emerging SARS-CoV-2 Variants in Patients With Secondary Immunodeficiency.

Authors:  Nathan M Markarian; Gaël Galli; Dhanesh Patel; Mark Hemmings; Priya Nagpal; Albert M Berghuis; Levon Abrahamyan; Silvia M Vidal
Journal:  Front Microbiol       Date:  2022-07-01       Impact factor: 6.064

3.  Inactivation and Recovery of High Quality RNA From Positive SARS-CoV-2 Rapid Antigen Tests Suitable for Whole Virus Genome Sequencing.

Authors:  Guerrino Macori; Tristan Russell; Gerald Barry; Siobhán C McCarthy; Leonard Koolman; Patrick Wall; Donal Sammin; Grace Mulcahy; Séamus Fanning
Journal:  Front Public Health       Date:  2022-05-03

4.  COVID-19 in patients with hematologic malignancy.

Authors:  Petra Langerbeins; Michael Hallek
Journal:  Blood       Date:  2022-07-21       Impact factor: 25.476

Review 5.  SARS-CoV-2 Variants, Vaccines, and Host Immunity.

Authors:  Priyal Mistry; Fatima Barmania; Juanita Mellet; Kimberly Peta; Adéle Strydom; Ignatius M Viljoen; William James; Siamon Gordon; Michael S Pepper
Journal:  Front Immunol       Date:  2022-01-03       Impact factor: 7.561

6.  SARS-CoV-2 Evolution and Spike-Specific CD4+ T-Cell Response in Persistent COVID-19 with Severe HIV Immune Suppression.

Authors:  Hortensia Álvarez; Ezequiel Ruiz-Mateos; Pedro Miguel Juiz-González; Joana Vitallé; Irene Viéitez; María Del Carmen Vázquez-Friol; Isabel Torres-Beceiro; Alberto Pérez-Gómez; Pilar Gallego-García; Nuria Estévez-Gómez; Loretta De Chiara; Eva Poveda; David Posada; Josep M Llibre
Journal:  Microorganisms       Date:  2022-01-11
  6 in total

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