[Membranous nephropathy].

"Membranous nephropathy Membranous nephropathy is the leading cause of nephrotic syndrome in adults, and results from immune complex deposition on the subepithelial surface of the glomerular basement membrane. Its outcome is unpredictable, and membranous nephropathy is associated with significant rates of kidney failure. The auto-immune nature of the disease was confirmed in the last decade with the discovery of a growing list of podocyte antigens targeted by autoantibodies, e.g. phospholipase A2 receptor (PLA2R). In the meantime, the management of patients with membranous nephropathy has changed dramatically through the evaluation of new therapeutic molecules, such as anti-B cell monoclonal antibodies, in clinical trials."