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Literature DB >> 34160751

Protective Effects of Zinc on Spinal Cord Injury.

Shan Wen¹, Yuanlong Li¹, Xiaolei Shen¹, Zhe Wang¹, Kaihua Zhang¹, Jiawei Zhang¹, Xifan Mei².

Abstract

Spinal cord injury is a serious disease of the central nervous system, but there is no effective treatment. And zinc is an essential nutrient for human body and participates in many physiological processes, such as immune response, homeostasis, oxidative stress, cell cycle progression, DNA replication, DNA damage repair, apoptosis, and aging. This article mainly summarizes that zinc could predict the prognosis and treat the spinal cord injury. Especially, zinc could help to inhibit inflammation, regulate autophagy, and reduce oxidative stress. However, excessive zinc will damage neurons.

Entities: Chemical

Keywords: Autophagy; Inflammation; Neuron; Oxidative stress; Spinal cord injury; Zinc

Mesh：

Substances：

Year: 2021 PMID： 34160751 DOI： 10.1007/s12031-021-01859-x

Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444

50 in total

1. Low-after-high glucose down-regulated Cx43 in H9c2 cells by autophagy activation via cross-regulation by the PI3K/Akt/mTOR and MEK/ERK_1/2 signal pathways.

Authors: Yaguang Bi; Guangyu Wang; Xiangdong Liu; Meng Wei; Qingyong Zhang
Journal: Endocrine Date: 2017-02-08 Impact factor: 3.633

2. Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.

Authors: Ramanjaneyulu Allam; Kate E Lawlor; Eric Chi-Wang Yu; Alison L Mildenhall; Donia M Moujalled; Rowena S Lewis; Francine Ke; Kylie D Mason; Michael J White; Katryn J Stacey; Andreas Strasser; Lorraine A O'Reilly; Warren Alexander; Benjamin T Kile; David L Vaux; James E Vince
Journal: EMBO Rep Date: 2014-07-02 Impact factor: 8.807

Protective Effects of Zinc on Spinal Cord Injury.

1. Low-after-high glucose down-regulated Cx43 in H9c2 cells by autophagy activation via cross-regulation by the PI3K/Akt/mTOR and MEK/ERK_1/2 signal pathways.

2. Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.

Review 3. Antioxidant role of zinc in diabetes mellitus.

Review 4. Recent aspects of the effects of zinc on human health.

5. Review of immune function, healing of pressure ulcers, and nutritional status in patients with spinal cord injury.

Review 6. Zinc and its role in immunity and inflammation.

7. Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning.

8. NMR-based insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub ligase.

Review 9. Inflammogenesis of Secondary Spinal Cord Injury.

Review 10. The Effect of Zinc on Post-neurosurgical Wound Healing: A Review.

Review 1. Zinc in Cognitive Impairment and Aging.

Protective Effects of Zinc on Spinal Cord Injury.

1. Low-after-high glucose down-regulated Cx43 in H9c2 cells by autophagy activation via cross-regulation by the PI3K/Akt/mTOR and MEK/ERK1/2 signal pathways.

2. Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.

Review 3. Antioxidant role of zinc in diabetes mellitus.

Review 4. Recent aspects of the effects of zinc on human health.

5. Review of immune function, healing of pressure ulcers, and nutritional status in patients with spinal cord injury.

Review 6. Zinc and its role in immunity and inflammation.

7. Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning.

8. NMR-based insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub ligase.

Review 9. Inflammogenesis of Secondary Spinal Cord Injury.

Review 10. The Effect of Zinc on Post-neurosurgical Wound Healing: A Review.

Review 1. Zinc in Cognitive Impairment and Aging.

1. Low-after-high glucose down-regulated Cx43 in H9c2 cells by autophagy activation via cross-regulation by the PI3K/Akt/mTOR and MEK/ERK_1/2 signal pathways.