Sexual function following pelvic fracture urethral injury and posterior urethroplasty.

BACKGROUND: To evaluate erectile and sexual function after pelvic fracture urethral injury (PFUI) by performing a retrospective review of a large multi-center database. We hypothesized that most men will have erectile dysfunction (ED) and poor sexual function following PFUI, which will remain after posterior urethroplasty.
METHODS: Using the Trauma and Urologic Reconstructive Networks of Surgeons (TURNS) database, we identified PFUI patients undergoing posterior urethroplasty. We excluded patients with incomplete demographic, surgical and/or questionnaire data. Sexual Health Inventory of Men (SHIM), Male Sexual Health Questionnaire (MSHQ), and subjective changes in penile curvature were collected before urethroplasty surgery and at follow-up. We performed descriptive statistics for erectile and ejaculatory function using STATA v12.
RESULTS: We identified 92 men meeting inclusion criteria; median age was 41.7 years and BMI was 26.5. The mechanism of injury was blunt in all patients, and average distraction defect length was 2.3 cm (SD 1.0 cm). In the 38 patients who completed both pre and post-operative SHIM questionnaires, the mean SHIM score was 10.5 (SD 7.0), with 63% having severe ED (SHIM <12). The median follow-up was 5.6 months and the mean post-operative SHIM was 9.3 (SD 6.5), with 68% having severe ED. The mean change in SHIM score was -1.18 (SD 6.29) with 6 (16%) patients reporting de novo ED (≥5 point decrease in score). Of the men with pre-operative MSHQ data, 46/74 (62.1%) had difficulty with ejaculation, 25/35 (71%) had change in penile length, and 6/33 (18%) reported penile curvature. In men with post-operative MSHQ, 19/44 (43%) expressed difficulty with ejaculation, 23/32 (72%) had change in penile length, and 9/33 (27%) reported penile curvature.
CONCLUSIONS: There is a high rate of severe ED, both following PFUI and remaining after posterior urethroplasty. Additionally, rates of ejaculatory difficulty and patient perceived changes in penile length and curvature underscore the complex nature of the impact of these injuries on sexual function beyond simple erectile function. 2021 Translational Andrology and Urology. All rights reserved.

Introduction

Pelvic fractures make up approximately 3% of all skeletal injuries, and the incidence among admitted trauma patients ranges from 8–9% (1-3). Furthermore, 2% of men with traumatic pelvic fracture have a concurrent pelvic fracture urethral injury (PFUI) (4,5). Improved trauma care and genitourinary reconstruction has led to improved survival and functional status in these patients (5-7). However these injuries can be devastating for men psychologically due to profound impact on their sexual function.

The rates of erectile dysfunction (ED) after pelvic fracture alone range from 5-28%, while the incidence of ED after PFUI is much higher, and varies widely in the literature from 26–76% (8-12). Urethral repair with posterior urethroplasty has demonstrated excellent long-term success rates, but long term erectile and sexual function assessment in these patients has been limited by the way the studies report ED, as mostly binary variables (yes vs. no) (6,13). All previously published rates of ED are from small single-center retrospective studies (14-18). These studies were also mostly limited by the lack of validated metrics, with only one study that used the International Index of Erectile Function (IIEF-5) for classifying ED (19).

Using the Trauma and Urologic Reconstructive Networks of Surgeons (TURNS) database, we sought to quantify erectile and sexual function using two validated questionnaires, the Sexual Health Inventory of Men (SHIM), selected questions from the Male Sexual Health Questionnaire (MSHQ), as well as non-validated questions about penile length and curvature. Also, we sought to accurately define changes in erectile and sexual function that occur following posterior urethroplasty. We hypothesize that the majority of men will have ED and poor sexual function following their injuries and there will be minimal change after posterior urethroplasty. We present the following article in accordance with the STROBE reporting checklist (available at http://dx.doi.org/10.21037/tau-20-1287).

Methods

We utilized the TURNS urethroplasty database to identify patients with PFUI who underwent posterior urethroplasty. TURNS is a multi-institutional group focused on urologic trauma and reconstruction, made up of 13 urologic surgeon members, who have an established prospectively collected database of urethroplasty patients (20). The TURNS group has published their long-term voiding outcomes in 122 patients that underwent posterior urethroplasty following PFUI, with a success rate of 91% (6). We reviewed the database of patients from 2009 to 2017, and identified 92 of the 122 patients who completed erectile and sexual function questionnaires either before, after, or both before and after urethroplasty. We excluded 30 patients that had no pre or post-urethroplasty SHIM/MSHQ data. We restricted our SHIM analysis to 38 patients with both pre and post urethroplasty data. With the MSHQ data this was not possible due to lack of patients with both pre and post urethroplasty data and instead the group responses were compared between pre and post urethroplasty, and change was not assessed in patients with complete pre and post urethroplasty data. Injuries were classified as blunt or penetrating. Pre-injury erectile function was not available.

All patients were managed with either endoscopic primary urethral realignment or suprapubic catheter (SPC), followed by delayed posterior urethroplasty repair. Adjunct maneuvers during posterior urethroplasty to achieve a tension free urethral anastomosis were noted and included: (I) abdominal-perineal approach; (II) corporal re-routing; (III) pubic symphysis resection; (IV) corporal splitting; (V) partial prostatectomy. The SHIM has been validated to measure ED in multiple settings and was administered along with the MSHQ, which assesses ejaculatory and other aspects of sexual function (21,22). SHIM & MSHQ data were obtained pre- and post-operatively at each follow-up. SHIM scores range from 1–25, with lower numbers signifying worse ED. To simplify our SHIM categories, the SHIM data were further stratified by the severity of ED: minimal >21, moderate 12–20 (combines both “mild and mild to moderate”), and severe <12 (combines both “moderate and severe”) (23). The MSHQ data obtained was limited to the following questions: how often have you been able to ejaculate, how would you rate the strength of ejaculate, how would you rate the amount of ejaculate, and the bothersome score for ejaculate. Therefore, we did not include a MSHQ composite score. Sexual function was further evaluated using non-validated questions of patient-perceived changes in penile length and curvature both pre- and post-operatively. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by the institutional review board of the University of Utah (IRB_00047027) and informed consent was taken from all the patients.

Statistical analysis

Descriptive statistics were performed using STATA v12. Two-sided t-tests were used to assess association of post-op ED with the following potential variables: initial catheter management, pelvic angioembolization (coil or gelfoam) during initial trauma management. Two sample rank-sum (Mann-Whitney) tests and chi-square tests were used to compare severe ED rates with adjunctive maneuvers at the time of posterior urethroplasty.

Results

Patient demographics and injury characteristics

In the 92 patients with questionnaire data available, the median age at injury was 41.7 years (IQR, 30–53.9 years) and median BMI was 26.5 (IQR, 22.9–31.1); mechanism of injury was blunt injury in all patients. The median distraction defect length was 2 cm (IQR, 2–3 cm). The median follow-up was 5.6 months (IQR, 4.1–7.8 months) after urethroplasty. Eight patients required angioembolization to control pelvic bleeding. Suprapubic catheter management just prior to urethroplasty was present in 62% of patients. Twenty-eight patients (30%) reported current or former smoking status ().

Table 1

Patient demographics and injury characteristics (N=92)

Patient variables	Total (%)
Age (years), median (IQR)	41.7 (30.0–53.9)
BMI, median (IQR)	26.5 (22.9–31.1)
Stricture length (cm), median (IQR)	2 [2–3]
Need for embolization
Unilateral	3
Bilateral	5
Medical co-morbidities
Current or former smokers	28
Diabetic	5
Hypertension	14
Hyperlipidemia	10
PVD or CAD	0
Adjunct procedures
Abdominal perineal approach	5
Corporal splitting	35
Corporal re-routing	1
Pubic symphysis resection	10
Partial prostatectomy	13

BMI, body mass index; PVD, peripheral vascular disease; CAD, coronary artery disease.

Patient reported sexual function (SHIM)

Of the 92 patients identified in the database, 74 (80.4%) completed pre-operative SHIM questionnaires; 44 (47.8% of the 92) completed post-operative SHIM questionnaires. There were 38 patients who completed both a pre and post-operative SHIM questionnaire, and were the focus of our ED analysis. The mean pre-operative SHIM score in the cohort of 38 patients was 10.5 (SD 7.0), which decreased (worsened) to 9.3 (SD 6.5) post-operatively. The rate of Severe ED (SHIM <12) was reported in 63% (24 of 38) pre-operatively and was not significantly different from the 68% (26 of 38) post-operatively (). The mean change in SHIM score was −1.18 (SD 6.29, not statistically significant) with 6 (16%) patients reporting de novo ED (≥5-point decrease in score).

Figure 1

SHIM scores before and after urethroplasty. Only includes the 38 patients who completed both the pre and post questionnaires. SHIM, sexual health inventory of men.

Patient reported sexual function (MSHQ, penile length and curvature)

There were 74 patients with MHSQ scores either pre or post urethroplasty. There were 46/74 (62.1%) patients that expressed difficulty with ejaculation (either unable to ejaculate or only able to ejaculate less than half of the time), and 51/74 (68.9%) that reported bother by their ejaculatory difficulties after PFUI. There were 25/35 (71%) men with reported change in penile length, and 6/33 (18%) reported penile curvature. In men with post-operative MSHQ, 19/44 (43%) expressed difficulty with ejaculation, 23/32 (72%) had change in penile length, and 9/33 (27%) reported penile curvature ().

Figure 2

Sexual dysfunction rates after injury and post-urethroplasty.

Adjunctive maneuvers

There were 45 (48.9%) patients that needed one or more of the following adjunct maneuvers at the time of surgery, including: corporal splitting (N=35), abdominal-perineal approach (N=5), corporal re-routing (N=1), pubic symphysis resection (n=10), or partial prostatectomy (N=13) (). There was no significant difference, but there was a trend towards worse post-operative SHIM score when we compared those patients with or without adjunct maneuvers at the time of urethroplasty (mean SHIM 7.6 vs. 10.8, P=0.19). When analyzing the subgroup of patients who underwent adjunctive maneuvers and had completed post-operative SHIM data, we found that adjunct maneuvers were more likely to have severe ED (P=0.043), compared to those without any adjunct maneuvers (). Suprapubic tube management pre-operatively was also not associated with a significant difference in post-operative SHIM score (SPT mean SHIM 9.5 vs. non-SPT mean 10.4, P=0.72). Four patients underwent microvascular revascularization surgery, with two patients requiring bilateral revascularization. Prior to urethroplasty 3 of 4 patients had a SHIM score of 5, and one patient reported SHIM 12. Unfortunately, 3 of 4 patients did not have follow up SHIM data, and the one patient with post-urethroplasty SHIM remained at 5 (most severe ED). Pelvic angioembolization at the time of injury, either uni- or bilaterally, did not significantly impact the mean SHIM score with all groups averaging SHIM scores in the severe range, and this was similar at both time points (P=0.99).

Table 2

Erectile function in patients who underwent adjunct surgical maneuvers and completed post op SHIM (N=43)

Adjuvant maneuvers	SHIM <12 (N=30)	SHIM >12 (N=13)	P value
Adjunct procedures at time of surgery (total patients)*	17	3	0.043**
Abdominal perineal approach	0	1
Corporal splitting	14	3
Corporal re-routing	1	0
Pubic symphysis resection	3	1
Partial prostatectomy	6	0

*, a single patient may have 1 or more adjunct procedures; **, of the patients with post-operative SHIM scores, having one or more adjunct procedures was associated with higher risk of severe ED (SHIM <12). SHIM, Sexual Health Inventory of Men; ED, erectile dysfunction.

Discussion

Using the TURNS multi-center, prospectively collected, database we identified patients with PFUI undergoing posterior urethroplasty and found high rates of severe erectile and sexual dysfunction. In our series, 63% of patients had severe ED after PFUI, and remained high at 68% following definitive surgical repair. While success rates for continence has been well studied, previous reports in these studies did not use validated metrics when reporting ED rates. We also report important sexual dysfunction metrics using the MSQH and non-validated questionnaires, which demonstrated PFUI patients have high rates of ejaculatory dysfunction, perceived loss of penile length, and new and bothersome penile curvature.

The mechanism of ED following PFUI is focused on the direct injury that both lacerates and often avulses the posterior urethra, while simultaneously injuring the penile nerves and arteries as they traverse the pelvic floor posterior to the apex of the prostate prior to entering the penis. There is debate and limited literature as to the contribution of neurogenic injury compared to direct vascular injury, but more evidence suggests that neurogenic ED is the more common etiology. One study supporting the neurogenic injury theory found that 24 of 27 (89%) of impotent men following PFUI responded to intracavernosal vasoactive medications (24). In a separate study, corpora cavernosal electromyogram in 5 of 8 men with PFUI and ED were abnormal despite normal vascular flow on duplex ultrasound (25). Arguments for vasculogenic ED etiology from PFUI are based on arteriographic studies that report occlusion rates as high as 92% of either internal pudendal or internal penile artery (26). Although controversial, revascularization of the internal pudendal arteries was reported to successfully treat ED in 82% of men with bilateral arterial occlusion following PFUI (27). In our study, only four patients (4.3%) underwent microvascular revascularization surgery for ED. Furthermore, the severity of ED was similar for men who required angioembolization during their initial trauma management compared to men without angioembolization. Both findings from our study would support the role of neurogenic ED for men with PFUI, but our study is likely underpowered to definitively describe the etiology of ED.

There is limited data that helps identify which patients will develop sexual dysfunction or ED following PFUI. Predictors of ED on multivariable analysis in pediatric patients, reported by Koraitim et al., included urethral gap distance >2.5 cm and lateral displacement of the prostate (15). Another study by Johnsen et al., found that only high grade urethral injury predicted ED (28). Our study showed mean gap distance of 2.3 cm, and our data did not include the direction of displacement or the American Association of Surgery for Trauma (AAST) Urethral Trauma Grading Scale.

Initial bladder management with either SPC vs. primary endoscopic realignment in the setting of PFUI is hotly debated, and is currently under study by the Multi-institutional Genitourinary Study Group supported by the AAST (29). One of questions in this study examines the impact of bladder management on long-term sexual function. Previous studies, including a meta-analysis have failed to show a significant difference in ED rates based on bladder management after PFUI, although SPC has trended towards higher rates of ED (30,31). One of the major limitations of the previous cohort studies and the meta-analysis was the lack of validated ED questionnaire data. In addition, those men that were treated with urethral realignment may have less severe injuries, creating selection bias and the appearance of better sexual function that is not actually related to their bladder management. In our cohort of men, SPC did not impact the severity of ED based on SHIM scores.

Many studies have attempted to determine the impact that posterior urethroplasty in PFUI patients has on erectile function. In the literature, the rate of improved erections following posterior urethroplasty ranged between 9–66%, and the rate of de novo ED ranged between 3% and 7% after PFUI (11,14,17,32,33). The largest series of posterior urethroplasty reported, from Joshi et al., described a 56% rate of ED pre- vs. 63% post-operatively, which was very similar to our findings (68% post-operative severe ED rate) (13). In our study, ED was worsened in 16% of patients after urethroplasty. This finding was also reported in the one other study that used a validated questionnaire, the IIEF, where patients diagnosed with neurogenic ED experienced worsening ED postoperatively (IIEF 15 pre- vs. 10 post-operatively) (19).

Sexual dysfunction following PFUI and posterior urethroplasty has even less available literature than ED. In one study, among 277 pelvic fracture patients surveyed, 46% of men reported sexual dysfunction; however, the definitions of sexual dysfunction were not well explained (34). In our study, 70% of patients following their injury experienced perceived penile length loss, and this proportion did not change after urethroplasty. Similarly, about one quarter of men reported penile curvature, both before and after surgery. If the loss of length or curvature was only seen post-operatively it would be simple to account for this based on the anastomotic nature of the repair, but this was present pre-operatively. Previous literature has described fibrosis of the corpora cavernosa associated with neurovascular injury after radical prostatectomy which can lead to penile shortening and ED (33). The mechanism of penile shortening after PFUI and posterior urethroplasty may be very similar. One study reported that patients with PFUI and posterior urethroplasty had decreased penile girth and length compared to traumatic anterior urethral stricture and subsequent urethroplasty (18). The one sexual function parameter that improved significantly in our study was ejaculatory function, with only 40% of men with ejaculatory dysfunction after posterior urethroplasty compared to 60% after their injury. Pre-urethroplasty the mechanism could be explained by the complete obliteration of the posterior urethra. After successful and patent anastomosis, the remaining ejaculatory dysfunction may be due to neurogenic dysfunction of the hypogastric somatic nerves necessary for antegrade emission or due to post-urethroplasty bulbospongiosus muscle dysfunction. The exact mechanism of ejaculatory dysfunction after anterior urethroplasty has remained elusive.

This study has many limitations. Most notably, patient follow-up, survey rates, and the multiple different surgeons can introduce potential uncontrolled biases. With multiple surgeons in the group, individual techniques may not fully be quantified even with this advanced database. Due to the rare nature and complexity of this injury, many of the patients travel great distances to be treated by the TURNS surgeons, and subsequently follow up with local urologists. This contributed to our moderate follow-up time. With a median follow-up time of 6 months, if we extrapolate data from prostatectomy, then it is likely that erectile and sexual function will continue to improve up to 12–18 months following the injury. Previous researchers have proposed that tissue edema, swelling, and inflammation are all causes of ED that may explain the transient deterioration of erectile function after surgery, and which may continue to improve beyond 6 months (35). An insufficient number of patients underwent penile revascularization prior to posterior urethroplasty and for this reason a subset analysis of the effects of revascularization on erectile and sexual function was not possible. We acknowledge that this study would be improved if all patients had complete sexual and erectile function questionnaires both pre- and post-urethroplasty. With this data it may be possible to see differences in functional outcomes based on adjunct maneuvers at that time of surgery, but there are many challenges obtaining sexual and erectile function data in this population.

While the majority of men have severe ED after PFUI, identifying the rare patients with preserved erectile and sexual function following PFUI is imperative for careful surgical planning and pre-operative counseling. We anxiously await results from the AAST randomized clinic trial for initial bladder management in PFUI, and look forward to any recommendations to improve the significant sexual and erectile morbidity experienced by these patients. The management of PFUI patients may benefit from a multi-disciplinary approach, including early referral to mental health. We also advocate for referral to our men’s health clinic for a penile rehabilitation program to help address and mitigate the effects of PFUI on erectile and sexual function.

Conclusions

ED is common after PFUI, with larger defects correlating with worse function. Urethroplasty appears to negatively affect erectile function in select patients. Other aspects of sexual function, including penile length, curvature and ejaculatory function, are also common, underscoring the complex nature of the impact of these injuries on sexual function beyond simple erectile function, and may serve to guide future management strategies in this patient population.

The article’s supplementary files as