Haley M Gonzales1, David J Taber2, Satish Nadig2, Neha Patel3, Angello Lin2, Prabhakar K Baliga2, Vinayak S Rohan2. 1. Department of Surgery, The Medical University of South Carolina, Charleston, SC, USA. Electronic address: gonzaleh@musc.edu. 2. Department of Surgery, The Medical University of South Carolina, Charleston, SC, USA. 3. Department of Pharmacy, The Medical University of South Carolina, Charleston, SC, USA.
Abstract
BACKGROUND: Racial disparities following pancreas transplantation (PTX) are poorly defined. METHODS: This was a large-scale, single-center, longitudinal cohort study including adult PTX recipients. Patients were grouped by race to allow for comparisons. RESULTS: 287 PTX recipients were included; 125 (43.5%) were African American (AA). At baseline, AAs had a significantly higher proportion of T2DM (19.4% vs. 5.7%, p = 0.001), were younger, and more likely to be female. AAs experienced significantly higher rates of pancreatic leaks and post-operative bleeding. PTX rejection was comparable, however, kidney rejection tended to be higher among AA SPKs. Long-term mean HgbA1C levels were significantly higher among AAs (6.9% vs. 6.3%, p = 0.039). Patient and graft survival was comparable between groups, but early patient survival tended to be lower in AAs. CONCLUSIONS: This study demonstrated significant perioperative health disparities among AA PTX recipients, including poorer glycemic control and more early deaths, despite similar long-term patient and graft survival.
BACKGROUND: Racial disparities following pancreas transplantation (PTX) are poorly defined. METHODS: This was a large-scale, single-center, longitudinal cohort study including adult PTX recipients. Patients were grouped by race to allow for comparisons. RESULTS: 287 PTX recipients were included; 125 (43.5%) were African American (AA). At baseline, AAs had a significantly higher proportion of T2DM (19.4% vs. 5.7%, p = 0.001), were younger, and more likely to be female. AAs experienced significantly higher rates of pancreatic leaks and post-operative bleeding. PTX rejection was comparable, however, kidney rejection tended to be higher among AA SPKs. Long-term mean HgbA1C levels were significantly higher among AAs (6.9% vs. 6.3%, p = 0.039). Patient and graft survival was comparable between groups, but early patient survival tended to be lower in AAs. CONCLUSIONS: This study demonstrated significant perioperative health disparities among AA PTX recipients, including poorer glycemic control and more early deaths, despite similar long-term patient and graft survival.
Authors: A Lo; R J Stratta; M F Egidi; M H Shokouh-Amiri; H P Grewal; A T Kizilisik; R R Alloway; A O Gaber Journal: Transplant Proc Date: 2001 Feb-Mar Impact factor: 1.066
Authors: Carlton J Young; Paul A MacLennan; Elinor C Mannon; Rhiannon D Reed; Brittany A Shelton; Michael J Hanaway; Gaurav Agarwal; Robert S Gaston; Bruce A Julian; Clifton E Kew; Vineeta Kumar; Roslyn B Mannon; Shikha Mehta; Song C Ong; Graham C Towns; Mark H Deierhoi; Jayme E Locke Journal: Ann Surg Date: 2020-01 Impact factor: 12.969
Authors: George W Burke; Dixon B Kaufman; J Michael Millis; A Osama Gaber; Christopher P Johnson; David E R Sutherland; Jeffrey D Punch; Barry D Kahan; Eugene Schweitzer; Alan Langnas; James Perkins; John Scandling; Waldo Concepcion; Mark D Stegall; James A Schulak; Paul F Gores; Enrico Benedetti; Gabriel Danovitch; Alice K Henning; Marilyn R Bartucci; Sarah Smith; William E Fitzsimmons Journal: Transplantation Date: 2004-04-27 Impact factor: 4.939