Prabhakaran Vasudevan1, Ranjith K Moorthy1, Grace Rebekah2, Ellen Jackson3,4,5, Betcy Evangeline Pamela1, Subashini Thamizhmaran1, Josephin Manoj1, Anupriya Thanigachalam1, Douglas Drevets6,7, Hélène Carabin3,4,5,8,9, Vedantam Rajshekhar1. 1. Department of Neurological Sciences, Christian Medical College, Vellore 632004, Tamilnadu, India. 2. Department of Biostatistics, Christian Medical College, Vellore 632004, Tamilnadu, India. 3. Department of Pathology and Microbiology, University of Montreal, Québec H3C 3J7, Canada. 4. Centre de Recherche en Santé Publique (CReSP), Québec H3C 3J7, Canada. 5. Groupe de Recherche en Épidémiologie des Zoonoses et Santé Publique (GREZOSP), Québec H3C 3J7, Canada. 6. Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City OK 73104, USA. 7. Medical Services, Dept. of Veterans Affairs Medical Center, Oklahoma City OK 73104, USA. 8. Department of Social and Preventive Medicine, University of Montreal, Québec H3C 3J7, Canada. 9. Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City OK 73104, USA.
Abstract
BACKGROUND: The presence of perilesional edema among patients with parenchymal neurocysticercosis (pNCC) of various lesion subtypes has not been correlated with results of serum enzyme-linked immunotransfer blot (EITB) for cysticercal antibodies. METHODS: In total, 521 patients with pNCC were classified into solitary cysticercus granuloma (SCG), multiple lesions, at least one of which was an enhancing granuloma (GMNCC), solitary calcified cysticercal lesion (SCC) and multiple calcified cysticercal lesions (CMNCC). The proportion of EITB positivity among each lesion subtype and its association with perilesional edema were determined. RESULTS: There were significantly higher positive EITB results in patients with GMNCC (90/111, 81.1%) compared with other lesion types. Perilesional edema was associated with positive EITB in patients with CMNCC. On univariate analysis, perilesional edema and GMNCC were associated with EITB positivity. On multivariate analysis, only GMNCC (OR 7.5; 95% CI 3.5 to 16.2) was significantly associated with EITB positivity. CONCLUSIONS: In patients with pNCC, the presence of perilesional edema is associated with a higher probability of a positive EITB result in patients with CMNCC, suggesting a synchronicity in the mechanisms associated with formation of perilesional edema and the antibody response in this subtype. In patients with enhancing granulomas, edema is not an independent predictor of a positive EITB, suggesting that the enhancement itself is associated with a strong antibody response.
BACKGROUND: The presence of perilesional edema among patients with parenchymal neurocysticercosis (pNCC) of various lesion subtypes has not been correlated with results of serum enzyme-linked immunotransfer blot (EITB) for cysticercal antibodies. METHODS: In total, 521 patients with pNCC were classified into solitary cysticercus granuloma (SCG), multiple lesions, at least one of which was an enhancing granuloma (GMNCC), solitary calcified cysticercal lesion (SCC) and multiple calcified cysticercal lesions (CMNCC). The proportion of EITB positivity among each lesion subtype and its association with perilesional edema were determined. RESULTS: There were significantly higher positive EITB results in patients with GMNCC (90/111, 81.1%) compared with other lesion types. Perilesional edema was associated with positive EITB in patients with CMNCC. On univariate analysis, perilesional edema and GMNCC were associated with EITB positivity. On multivariate analysis, only GMNCC (OR 7.5; 95% CI 3.5 to 16.2) was significantly associated with EITB positivity. CONCLUSIONS: In patients with pNCC, the presence of perilesional edema is associated with a higher probability of a positive EITB result in patients with CMNCC, suggesting a synchronicity in the mechanisms associated with formation of perilesional edema and the antibody response in this subtype. In patients with enhancing granulomas, edema is not an independent predictor of a positive EITB, suggesting that the enhancement itself is associated with a strong antibody response.
Authors: Theodore E Nash; E Javier Pretell; Andres G Lescano; Javier A Bustos; Robert H Gilman; Armando E Gonzalez; Héctor H Garcia Journal: Lancet Neurol Date: 2008-11-03 Impact factor: 44.182
Authors: Jesica A Herrick; Biswajit Maharathi; Jin Suh Kim; Gerardo G Abundis; Anjali Garg; Isidro Gonzales; Herbert Saavedra; Javier A Bustos; Hector H Garcia; Jeffrey A Loeb Journal: Ann Clin Transl Neurol Date: 2018-04-10 Impact factor: 4.511