António Batista1, Rui Osório2, Ana Varela2, Patrícia Guilherme2, Ana Marreiros1,3,4, Sandra Pais1,3,4,5, Hipólito Nzwalo6,7,8,9. 1. Faculty of Medicine and Biomedical Sciences and Medicine, University of Algarve, Edifício 7, Ala Norte, Ala Nascente-3° andar, Campus de Gambelas, 8005-139, Faro, Portugal. 2. Stroke Unit, Centro Hospitalar Universitário do Algarve, Algarve, Portugal Centro Hospitalar Universitário do Algarve (CHUA)-R. Leão Penedo, 8000-386, Faro, Portugal. 3. ABC-RI, Algarve Biomedical Center Research Institute, Faro, Portugal. 4. International Centre on Ageing (CENIE), Campus Gambelas, 8005-139, Faro, Portugal. 5. Comprehensive Health Research Centre (CHRC), Lisboa, Portugal. 6. Faculty of Medicine and Biomedical Sciences and Medicine, University of Algarve, Edifício 7, Ala Norte, Ala Nascente-3° andar, Campus de Gambelas, 8005-139, Faro, Portugal. nzwalo@gmail.com. 7. Stroke Unit, Centro Hospitalar Universitário do Algarve, Algarve, Portugal Centro Hospitalar Universitário do Algarve (CHUA)-R. Leão Penedo, 8000-386, Faro, Portugal. nzwalo@gmail.com. 8. ABC-RI, Algarve Biomedical Center Research Institute, Faro, Portugal. nzwalo@gmail.com. 9. International Centre on Ageing (CENIE), Campus Gambelas, 8005-139, Faro, Portugal. nzwalo@gmail.com.
Abstract
AIM: The incidence of spontaneous intracerebral hemorrhage (SICH) increases with age. Data on SICH mortality in the very old are sparse. We aimed to describe the predictors of 30-day SICH mortality in the very elderly in southern Portugal. METHODS: A total of 256 community representative SICH patients aged ≥ 75 years (2009-2016) were included. Multiple logistic regression was used to identify predictors of 30-day mortality. RESULTS: Mean age was 82.1 years; 57.4% males. The 30-day case fatality was 38.7%. The frequency of patients taking anticoagulants (29.3% vs. 11.5%); comatose (46.9% vs. 2.5%); with hematoma volume ≥ 30 mL (64.6% vs. 13.4%); intraventricular dissection (78.8% vs. 27.4%) was higher in deceased patients (p < 0.05). Survivors were more often admitted to stroke unit (SU) (68.2 vs. 31.3%) and had lower mean admission glycaemia values (p < 0.05). The likelihood of death was increased in patients with higher admission hematoma volume (≥ 30 mL) (OR: 8.817, CI 1.753-44.340, p = 0.008) and with prior to SICH history of ≥ 2 hospitalizations OR = 1.022, CI 1.009-1.069, p = 0.031). Having higher Glasgow coma scale score, OR: 0.522, CI 0.394-0.692, p < 0.001, per unit was associated with reduced risk of death. Age was not an independent risk factor of short-term death. CONCLUSIONS: The short-term mortality is high in very elderly SICH. Prior to SICH history of hospitalization, an indirect and gross marker of coexistent functional reserve, not age per se, increases the risk of short-term death. Other predictors of short-term death are potentially manageable reinforcing the message against any defeatist attitude toward elderly patients with SICH.
AIM: The incidence of spontaneous intracerebral hemorrhage (SICH) increases with age. Data on SICH mortality in the very old are sparse. We aimed to describe the predictors of 30-day SICH mortality in the very elderly in southern Portugal. METHODS: A total of 256 community representative SICH patients aged ≥ 75 years (2009-2016) were included. Multiple logistic regression was used to identify predictors of 30-day mortality. RESULTS: Mean age was 82.1 years; 57.4% males. The 30-day case fatality was 38.7%. The frequency of patients taking anticoagulants (29.3% vs. 11.5%); comatose (46.9% vs. 2.5%); with hematoma volume ≥ 30 mL (64.6% vs. 13.4%); intraventricular dissection (78.8% vs. 27.4%) was higher in deceased patients (p < 0.05). Survivors were more often admitted to stroke unit (SU) (68.2 vs. 31.3%) and had lower mean admission glycaemia values (p < 0.05). The likelihood of death was increased in patients with higher admission hematoma volume (≥ 30 mL) (OR: 8.817, CI 1.753-44.340, p = 0.008) and with prior to SICH history of ≥ 2 hospitalizations OR = 1.022, CI 1.009-1.069, p = 0.031). Having higher Glasgow coma scale score, OR: 0.522, CI 0.394-0.692, p < 0.001, per unit was associated with reduced risk of death. Age was not an independent risk factor of short-term death. CONCLUSIONS: The short-term mortality is high in very elderly SICH. Prior to SICH history of hospitalization, an indirect and gross marker of coexistent functional reserve, not age per se, increases the risk of short-term death. Other predictors of short-term death are potentially manageable reinforcing the message against any defeatist attitude toward elderly patients with SICH.
Authors: Charlotte Jj van Asch; Merel Ja Luitse; Gabriël Je Rinkel; Ingeborg van der Tweel; Ale Algra; Catharina Jm Klijn Journal: Lancet Neurol Date: 2010-01-05 Impact factor: 44.182
Authors: Erwin Chiquete; M Carmen Ruiz-Sandoval; Lucía E Alvarez-Palazuelos; Juan J Padilla-Martínez; Salvador González-Cornejo; José L Ruiz-Sandoval Journal: Cerebrovasc Dis Date: 2007-06-27 Impact factor: 2.762