Steven F Ziegler1. 1. Center for Fundamental Immunology, Benaroya Research Institute at Virginia Mason, Seattle, Washington; Department of Immunology, University of Washington School of Medicine, Seattle, Washington. Electronic address: sziegler@benaroyaresearch.org.
Abstract
OBJECTIVE: Atopic dermatitis often precedes the development of other atopic diseases, and the atopic march describes this temporal relationship in the natural history of these diseases. Although the pathophysiological mechanisms that underlie this relationship are poorly understood, epidemiologic and genetic data have suggested that the skin might be an important route of sensitization to allergens. DATA SOURCES: Review of recent studies on the role of skin barrier defects in systemic allergen sensitization. STUDY SELECTIONS: Recent publications on the relationship between skin barrier defects and expression of epithelial cell-derived cytokines. RESULTS: Animal models have begun to elucidate on how skin barrier defects can lead to systemic allergen sensitization. Emerging data now suggest that epithelial cell-derived cytokines, such as thymic stromal lymphopoietin, drive the progression from atopic dermatitis to asthma and food allergy. Skin barrier defects can lead to induction of epithelial cell-derived cytokines, which in turn leads to the initiation and maintenance of allergic inflammation and the atopic march. CONCLUSION: Development of new biologic drug targeting type 2 cytokines provides novel therapeutic interventions for atopic dermatitis.
OBJECTIVE: Atopic dermatitis often precedes the development of other atopic diseases, and the atopic march describes this temporal relationship in the natural history of these diseases. Although the pathophysiological mechanisms that underlie this relationship are poorly understood, epidemiologic and genetic data have suggested that the skin might be an important route of sensitization to allergens. DATA SOURCES: Review of recent studies on the role of skin barrier defects in systemic allergen sensitization. STUDY SELECTIONS: Recent publications on the relationship between skin barrier defects and expression of epithelial cell-derived cytokines. RESULTS: Animal models have begun to elucidate on how skin barrier defects can lead to systemic allergen sensitization. Emerging data now suggest that epithelial cell-derived cytokines, such as thymic stromal lymphopoietin, drive the progression from atopic dermatitis to asthma and food allergy. Skin barrier defects can lead to induction of epithelial cell-derived cytokines, which in turn leads to the initiation and maintenance of allergic inflammation and the atopic march. CONCLUSION: Development of new biologic drug targeting type 2 cytokines provides novel therapeutic interventions for atopic dermatitis.
Authors: S Chavanas; C Bodemer; A Rochat; D Hamel-Teillac; M Ali; A D Irvine; J L Bonafé; J Wilkinson; A Taïeb; Y Barrandon; J I Harper; Y de Prost; A Hovnanian Journal: Nat Genet Date: 2000-06 Impact factor: 38.330
Authors: Hai-Chon Lee; Mark B Headley; Yueh-Ming Loo; Aaron Berlin; Michael Gale; Jason S Debley; Nicholas W Lukacs; Steven F Ziegler Journal: J Allergy Clin Immunol Date: 2012-09-13 Impact factor: 10.793
Authors: Vassili Soumelis; Pedro A Reche; Holger Kanzler; Wei Yuan; Gina Edward; Bernhart Homey; Michel Gilliet; Steve Ho; Svetlana Antonenko; Annti Lauerma; Kathleen Smith; Daniel Gorman; Sandra Zurawski; Jon Abrams; Satish Menon; Terri McClanahan; Rene de Waal-Malefyt Rd; Fernando Bazan; Robert A Kastelein; Yong-Jun Liu Journal: Nat Immunol Date: 2002-06-10 Impact factor: 25.606
Authors: Rui He; Michiko K Oyoshi; Lilit Garibyan; Lalit Kumar; Steven F Ziegler; Raif S Geha Journal: Proc Natl Acad Sci U S A Date: 2008-08-18 Impact factor: 11.205
Authors: L S Park; U Martin; K Garka; B Gliniak; J P Di Santo; W Muller; D A Largaespada; N G Copeland; N A Jenkins; A G Farr; S F Ziegler; P J Morrissey; R Paxton; J E Sims Journal: J Exp Med Date: 2000-09-04 Impact factor: 14.307