Literature DB >> 34152794

Integrative Multiomics Approaches for Discovery of New Drug Targets for Cardiovascular Disease.

Muredach P Reilly1, Karin E Bornfeldt2,3.   

Abstract

Entities:  

Keywords:  Editorials; macrophages; peroxisome proliferator-activated receptors; proteomics; transplants; veins

Mesh：

Substances：

Year:  2021        PMID： 34152794      PMCID： PMC8221103          DOI： 10.1161/CIRCULATIONAHA.121.054900

Source DB:  PubMed          Journal:  Circulation        ISSN： 0009-7322            Impact factor:   39.918


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  15 in total

Review 1.  Single Cell RNA Sequencing in Atherosclerosis Research.

Authors:  Jesse W Williams; Holger Winkels; Christopher P Durant; Konstantin Zaitsev; Yanal Ghosheh; Klaus Ley
Journal:  Circ Res       Date:  2020-04-23       Impact factor: 17.367

2.  The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis.

Authors:  Nathalie Hennuyer; Isabelle Duplan; Charlotte Paquet; Jonathan Vanhoutte; Eloise Woitrain; Véronique Touche; Sophie Colin; Emmanuelle Vallez; Sophie Lestavel; Philippe Lefebvre; Bart Staels
Journal:  Atherosclerosis       Date:  2016-03-04       Impact factor: 5.162

3.  Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver.

Authors:  Sana Raza-Iqbal; Toshiya Tanaka; Motonobu Anai; Takeshi Inagaki; Yoshihiro Matsumura; Kaori Ikeda; Akashi Taguchi; Frank J Gonzalez; Juro Sakai; Tatsuhiko Kodama
Journal:  J Atheroscler Thromb       Date:  2015-06-04       Impact factor: 4.928

4.  Reaching completion for GTEx.

Authors:  Darren J Burgess
Journal:  Nat Rev Genet       Date:  2020-12       Impact factor: 53.242

Review 5.  The Forgotten Lipids: Triglycerides, Remnant Cholesterol, and Atherosclerotic Cardiovascular Disease Risk.

Authors:  Pratik B Sandesara; Salim S Virani; Sergio Fazio; Michael D Shapiro
Journal:  Endocr Rev       Date:  2019-04-01       Impact factor: 19.871

6.  Prevention of the angiographic progression of coronary and vein-graft atherosclerosis by gemfibrozil after coronary bypass surgery in men with low levels of HDL cholesterol. Lopid Coronary Angiography Trial (LOCAT) Study Group.

Authors:  M H Frick; M Syvänne; M S Nieminen; H Kauma; S Majahalme; V Virtanen; Y A Kesäniemi; A Pasternack; M R Taskinen
Journal:  Circulation       Date:  1997-10-07       Impact factor: 29.690

7.  Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human.

Authors:  Huize Pan; Chenyi Xue; Benjamin J Auerbach; Mingyao Li; Muredach P Reilly; Jiaxin Fan; Alexander C Bashore; Jian Cui; Dina Y Yang; Sarah B Trignano; Wen Liu; Jianting Shi; Chinyere O Ihuegbu; Erin C Bush; Jeremy Worley; Lukas Vlahos; Pasquale Laise; Robert A Solomon; Edward S Connolly; Andrea Califano; Peter A Sims; Hanrui Zhang
Journal:  Circulation       Date:  2020-09-23       Impact factor: 29.690

Review 8.  Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study.

Authors:  Aruna D Pradhan; Nina P Paynter; Brendan M Everett; Robert J Glynn; Pierre Amarenco; Marshall Elam; Henry Ginsberg; William R Hiatt; Shun Ishibashi; Wolfgang Koenig; Børge G Nordestgaard; Jean-Charles Fruchart; Peter Libby; Paul M Ridker
Journal:  Am Heart J       Date:  2018-09-29       Impact factor: 4.749

9.  Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease: PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development.

Authors:  Julius L Decano; Sasha A Singh; Cauê Gasparotto Bueno; Lang Ho Lee; Arda Halu; Sarvesh Chelvanambi; Joan T Matamalas; Hengmin Zhang; Andrew K Mlynarchik; Jiao Qiao; Amitabh Sharma; Shin Mukai; Jianguo Wang; Daniel G Anderson; C Keith Ozaki; Peter Libby; Elena Aikawa; Masanori Aikawa
Journal:  Circulation       Date:  2021-04-06       Impact factor: 39.918

10.  Effect of pemafibrate (K-877), a novel selective peroxisome proliferator-activated receptor α modular (SPPARMα), in atherosclerosis model using low density lipoprotein receptor knock-out swine with balloon injury.

Authors:  Hirokazu Konishi; Katsumi Miyauchi; Akira Onishi; Shunichi Suzuki; Daiichiro Fuchimoto; Jun Shitara; Hirohisa Endo; Hideki Wada; Shinichiro Doi; Ryo Naito; Manabu Ogita; Tomotaka Dohi; Takatoshi Kasai; Hiroyuki Daida
Journal:  PLoS One       Date:  2020-11-17       Impact factor: 3.240
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  1 in total

Review 1.  The role of multi-omics in the diagnosis of COVID-19 and the prediction of new therapeutic targets.

Authors:  Jianli Ma; Yuwei Deng; Minghui Zhang; Jinming Yu
Journal:  Virulence       Date:  2022-12       Impact factor: 5.428
  1 in total

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