Literature DB >> 3415271

[Antitumor activity of CPT-11 against rat Walker 256 carcinoma].

T Furuta1, T Yokokura, M Mutai.   

Abstract

The antitumor activity of CPT-11 on rat Walker 256 carcinoma was investigated. Intraperitoneal, intravenous or oral administration of CPT-11 caused a remarkable prolongation of the life span of Wistar rat implanted with Walker 256 intraperitoneally. Intravenous injection and oral administration of CPT-11 markedly inhibited the growth of subcutaneously implanted Walker 256. CPT-11 showed a considerable antitumor activity by continuous intravenous injection against the solid type Walker 256.

Entities:  

Mesh:

Substances:

Year:  1988        PMID: 3415271

Source DB:  PubMed          Journal:  Gan To Kagaku Ryoho        ISSN: 0385-0684


  3 in total

1.  Antitumor activity of a camptothecin derivative, CPT-11, against human tumor xenografts in nude mice.

Authors:  Y Kawato; T Furuta; M Aonuma; M Yasuoka; T Yokokura; K Matsumoto
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

2.  Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11.

Authors:  E Araki; M Ishikawa; M Iigo; T Koide; M Itabashi; A Hoshi
Journal:  Jpn J Cancer Res       Date:  1993-06

3.  Inhibition of UDP-glucuronosyltransferase by aglycons of natural glucuronides in kampo medicines using SN-38 as a substrate.

Authors:  T Yokoi; M Narita; E Nagai; H Hagiwara; M Aburada; T Kamataki
Journal:  Jpn J Cancer Res       Date:  1995-10
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.