| Literature DB >> 34151805 |
Alina Solomon1,2, Ron Handels3,4, Anders Wimo4, Riitta Antikainen5,6,7, Tiina Laatikainen8,9,10, Esko Levälahti8, Markku Peltonen8, Hilkka Soininen1,11, Timo Strandberg5,12, Jaakko Tuomilehto8,13,14, Miia Kivipelto1,2,9,15, Tiia Ngandu2,8.
Abstract
We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 %CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.Entities:
Keywords: Clinical trial; dementia; dementia risk score; lifestyle intervention; prevention
Year: 2021 PMID： 34151805 DOI： 10.3233/JAD-210331
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472