Wen-Ling Li1, Hua Sang1, Xin Xu1, Yuan-Yuan Zhang2, Jie Gao1, Bo-Hua Chen1, Xiang-Ying Meng3. 1. Department of Pharmacy, Affiliated Hospital of Nantong University Nantong 226001, Jiangsu, China. 2. Department of Neurology, Affiliated Hospital of Nantong University Nantong 226001, Jiangsu, China. 3. Department of Pharmacy, Affiliated RICH Hospital of Nantong University Nantong 226010, Jiangsu, China.
Abstract
PURPOSE: To explore the correlation of changes in homocysteine (HCY) l, blood lipids and blood glucose levels in patients with cerebral infarction. METHODS: 120 patients with cerebral infarction admitted to our hospital from February 2018 to February 2020 were selected as the experimental group, and 120 healthy volunteers in the same period were selected as the control group. The blood pressure and the homocysteine, blood lipids, blood glucose levels were compared; the experimental group was subdivided into single cerebral infarction group, combined diabetes group and combined hypertension group, and their blood lipid levels were compared with the control group; Spearman method was used to analyze the relationship between HCY, blood lipid, blood sugar levels and cerebral infarction. RESULTS: ① The diastolic and systolic blood pressure levels of the experimental group were higher, whereas the control group were lower (P<0.05). ② The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and TC/[high density lipoprotein cholesterol (HDL-C)] of the experimental group were higher, but the level of HDL-C was lower than that of the control group (all P<0.05). ③ The fasting blood glucose (FBG) and glycosylated hemoglobin (GHb) levels of the experimental group were higher than those of the control group (all P<0.05). ④ The HCY level in the experimental group was higher than that in the control group (P<0.05). ⑤ The levels of TC, TG, LDL-C and TC/HDL-C in single cerebral infarction group, combined diabetes group and combined hypertension group were higher, and HDL-C level was lower than that in control group (all P<0.05). ⑥ Spearman analysis revealed that HCY was positively correlated with TC, TG, LDL-C and FBG (all P<0.05). CONCLUSION: The level of HCY is positively correlated with the levels of TC, TG, LDL-C and FBG in patients with cerebral infarction. AJTR
PURPOSE: To explore the correlation of changes in homocysteine (HCY) l, blood lipids and blood glucose levels in patients with cerebral infarction. METHODS: 120 patients with cerebral infarction admitted to our hospital from February 2018 to February 2020 were selected as the experimental group, and 120 healthy volunteers in the same period were selected as the control group. The blood pressure and the homocysteine, blood lipids, blood glucose levels were compared; the experimental group was subdivided into single cerebral infarction group, combined diabetes group and combined hypertension group, and their blood lipid levels were compared with the control group; Spearman method was used to analyze the relationship between HCY, blood lipid, blood sugar levels and cerebral infarction. RESULTS: ① The diastolic and systolic blood pressure levels of the experimental group were higher, whereas the control group were lower (P<0.05). ② The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and TC/[high density lipoprotein cholesterol (HDL-C)] of the experimental group were higher, but the level of HDL-C was lower than that of the control group (all P<0.05). ③ The fasting blood glucose (FBG) and glycosylated hemoglobin (GHb) levels of the experimental group were higher than those of the control group (all P<0.05). ④ The HCY level in the experimental group was higher than that in the control group (P<0.05). ⑤ The levels of TC, TG, LDL-C and TC/HDL-C in single cerebral infarction group, combined diabetes group and combined hypertension group were higher, and HDL-C level was lower than that in control group (all P<0.05). ⑥ Spearman analysis revealed that HCY was positively correlated with TC, TG, LDL-C and FBG (all P<0.05). CONCLUSION: The level of HCY is positively correlated with the levels of TC, TG, LDL-C and FBG in patients with cerebral infarction. AJTR
Authors: Sabine M J Welten; Rob C M de Jong; Anouk Wezel; Margreet R de Vries; Martin C Boonstra; Laura Parma; J Wouter Jukema; Tetje C van der Sluis; Ramon Arens; Ilze Bot; Sudhir Agrawal; Paul H A Quax; A Yaël Nossent Journal: Atherosclerosis Date: 2017-04-13 Impact factor: 5.162
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