Hui Liu1, Xiangying Li2, Rihui Chen1, Dingcheng Liu1, Chao Tong1. 1. Department of Interventional Radiology, Central South University, Xiangya School of Medicine Affiliated Haikou Hospital Haikou, Hainan Province, China. 2. Department of Radiology, Central South University, Xiangya School of Medicine Affiliated Haikou Hospital Haikou, Hainan Province, China.
Abstract
OBJECTIVE: To investigate the influence of left gastric artery embolization (LGAE) on obesity and Ghrelin/Leptin levels in pigs. METHODS: Healthy female Wuzhishan piglets aged 3-4 months were allocated into obesity + LGAE group, obesity group, control group (fed with a normal diet; n=8 for each group). Body weight, serum Ghrelin, Leptin, glucose and insulin levels were compared before surgery, 1 month and 3 months after surgery. RESULTS: Piglets in obesity group and obesity + LGAE group were heavier than those in control group before and 1 month after surgery (P<0.001), and in obesity group were heavier than those in obesity + LGAE group 1 month after surgery (P<0.05). A significant decrease in body weight was observed in obesity + LGAE group 3 months after surgery (P<0.05), and the obesity group showed heavier weight than the other two groups (P<0.001). Ghrelin levels in obesity group and obesity + LGAE group were higher than those in control group before and 1 month after surgery (P<0.001), and in obesity group were higher than those in obesity + LGAE group 1 month after surgery (P<0.05). They showed an evident decrease in obesity + LGAE group 3 months after surgery (P<0.05), and in obesity group were higher than that in the other two groups (P<0.01). Leptin levels in obesity group and obesity + LGAE group were higher than those in control group before surgery (P<0.01) and 1 month after surgery (P<0.05). They decreased significantly in obesity + LGAE group 3 months after surgery (P<0.01), and in obesity group were higher than those in the other two groups (P<0.01). CONCLUSION: LGAE greatly contributes to weight loss possibly by reducing the secretion of Ghrelin and Leptin. AJTR
OBJECTIVE: To investigate the influence of left gastric artery embolization (LGAE) on obesity and Ghrelin/Leptin levels in pigs. METHODS: Healthy female Wuzhishan piglets aged 3-4 months were allocated into obesity + LGAE group, obesity group, control group (fed with a normal diet; n=8 for each group). Body weight, serum Ghrelin, Leptin, glucose and insulin levels were compared before surgery, 1 month and 3 months after surgery. RESULTS: Piglets in obesity group and obesity + LGAE group were heavier than those in control group before and 1 month after surgery (P<0.001), and in obesity group were heavier than those in obesity + LGAE group 1 month after surgery (P<0.05). A significant decrease in body weight was observed in obesity + LGAE group 3 months after surgery (P<0.05), and the obesity group showed heavier weight than the other two groups (P<0.001). Ghrelin levels in obesity group and obesity + LGAE group were higher than those in control group before and 1 month after surgery (P<0.001), and in obesity group were higher than those in obesity + LGAE group 1 month after surgery (P<0.05). They showed an evident decrease in obesity + LGAE group 3 months after surgery (P<0.05), and in obesity group were higher than that in the other two groups (P<0.01). Leptin levels in obesity group and obesity + LGAE group were higher than those in control group before surgery (P<0.01) and 1 month after surgery (P<0.05). They decreased significantly in obesity + LGAE group 3 months after surgery (P<0.01), and in obesity group were higher than those in the other two groups (P<0.01). CONCLUSION: LGAE greatly contributes to weight loss possibly by reducing the secretion of Ghrelin and Leptin. AJTR
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