Juan Xie1, Xuan Zhou1, Lin Fang1, Jun Xiong1, Xiaoling Tao1. 1. Department of Gynecology, Hubei Maternal and Child Health Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology Wuhan 430070, Hubei Province, China.
Abstract
OBJECTIVE: This research was designed to probe into the clinical significance of anti-mullerian hormone (AMH) levels in early missed abortion. METHODS: Forty-six women with early missed abortions treated in our hospital from October 2018 to June 2019 were collected as the research subjects and included in the observation group (OG), while 51 normal pregnant women were included in the control group (CG) during the same period. The levels of AMH, human follicle stimulating hormone (FSH) and human luteinizing hormone (LH) in the serum of women of both groups were tested by enzyme-linked immunosorbent assay (ELISA). The diagnostic value of AMH in early missed abortion was analyzed by receiver operating characteristic (ROC). The correlation between AMH and FSH, LH was assessed via Pearson correlation. According to the median expression of AMH before treatment, patients were divided into high and low expression groups (HEG, LEG, respectively), and time of vaginal bleeding and menstrual resurgence, and the incidence of coagulation dysfunction were compared after operation. RESULTS: The AMH and FSH levels in serum of patients in the OG were obviously lower than those in the CG, and the LH level was markedly higher. The area under the curve of serum AMH was 0.867. AMH was positively correlated with FSH and negatively correlated with LH. The time of vaginal bleeding and menstruation resurgence of the HEG patients were remarkably lower than those of the LEG (All P < 0.05). CONCLUSION: Serum AMH level is expected to be a good prognostic indicator in diagnosing early missed abortion. AJTR
OBJECTIVE: This research was designed to probe into the clinical significance of anti-mullerian hormone (AMH) levels in early missed abortion. METHODS: Forty-six women with early missed abortions treated in our hospital from October 2018 to June 2019 were collected as the research subjects and included in the observation group (OG), while 51 normal pregnant women were included in the control group (CG) during the same period. The levels of AMH, human follicle stimulating hormone (FSH) and human luteinizing hormone (LH) in the serum of women of both groups were tested by enzyme-linked immunosorbent assay (ELISA). The diagnostic value of AMH in early missed abortion was analyzed by receiver operating characteristic (ROC). The correlation between AMH and FSH, LH was assessed via Pearson correlation. According to the median expression of AMH before treatment, patients were divided into high and low expression groups (HEG, LEG, respectively), and time of vaginal bleeding and menstrual resurgence, and the incidence of coagulation dysfunction were compared after operation. RESULTS: The AMH and FSH levels in serum of patients in the OG were obviously lower than those in the CG, and the LH level was markedly higher. The area under the curve of serum AMH was 0.867. AMH was positively correlated with FSH and negatively correlated with LH. The time of vaginal bleeding and menstruation resurgence of the HEG patients were remarkably lower than those of the LEG (All P < 0.05). CONCLUSION: Serum AMH level is expected to be a good prognostic indicator in diagnosing early missed abortion. AJTR
Authors: Sarah C M Roberts; Ushma D Upadhyay; Guodong Liu; Jennifer L Kerns; Djibril Ba; Nancy Beam; Douglas L Leslie Journal: JAMA Date: 2018-06-26 Impact factor: 56.272
Authors: Allison A Eubanks; Carrie J Nobles; Micah J Hill; Alan H DeCherney; Keewan Kim; Lindsey A Sjaarda; Neil J Perkins; Aijun Ye; Jessica R Zolton; Robert M Silver; Enrique F Schisterman; Sunni L Mumford Journal: Reprod Toxicol Date: 2020-09-09 Impact factor: 3.143