OBJECTIVE: To inquire into the significance of coagulation indexes in the progression of cirrhosis. METHODS: A total of 108 patients with cirrhosis treated in our hospital were collected as the research group (RG), and 105 healthy people who underwent concurrent physical examination were selected as the control group (CG). The coagulation indexes of all the participants were tested to determine their significance in cirrhosis progression. RESULTS: Compared with the CG, prothrombin time (PT), activated partial thrombin time (APTT) and thrombin time (TT) in the RG were statistically prolonged, while fibrinogen (FIB) was notably decreased (P<0.05). With the increase of Child-Pugh score, PT, APTT and TT prolonged and FIB reduced gradually (P<0.05). The coagulation indexes of patients were correlated with Child-Pugh score (P<0.05). Patients in the RG showed markedly higher alanine aminotransferase (ALT), total bilirubin (TBil), total bile acid (TBA), mean platelet volume (MPV), platelet distribution width (PDW) and platelet-large cell ratio (P-LCR), with notably lower albumin (ALB), prealbumin (PA), platelet count (PLT) and coagulation factors compared with the CG. As the Child-Pugh score increased, the ALT, TBil, TBA, MPV, PDW and P-LCR gradually elevated in the RG (P<0.05), whilst coagulation factors, ALB, PLT and PA all gradually decreased (P<0.05). The value of area under the curve (AUC) of each coagulation index for early diagnosis of cirrhosis was >0.80, and the sensitivity was >80% (P<0.05). CONCLUSION: Coagulation indexes, coagulation factors, platelet parameters and liver function all effectively reflect the level of liver injury; especially which, coagulation indexes are related to the severity of liver injury, and can provide evidence for the early diagnosis of cirrhosis patients, with clinical significance. AJTR
OBJECTIVE: To inquire into the significance of coagulation indexes in the progression of cirrhosis. METHODS: A total of 108 patients with cirrhosis treated in our hospital were collected as the research group (RG), and 105 healthy people who underwent concurrent physical examination were selected as the control group (CG). The coagulation indexes of all the participants were tested to determine their significance in cirrhosis progression. RESULTS: Compared with the CG, prothrombin time (PT), activated partial thrombin time (APTT) and thrombin time (TT) in the RG were statistically prolonged, while fibrinogen (FIB) was notably decreased (P<0.05). With the increase of Child-Pugh score, PT, APTT and TT prolonged and FIB reduced gradually (P<0.05). The coagulation indexes of patients were correlated with Child-Pugh score (P<0.05). Patients in the RG showed markedly higher alanine aminotransferase (ALT), total bilirubin (TBil), total bile acid (TBA), mean platelet volume (MPV), platelet distribution width (PDW) and platelet-large cell ratio (P-LCR), with notably lower albumin (ALB), prealbumin (PA), platelet count (PLT) and coagulation factors compared with the CG. As the Child-Pugh score increased, the ALT, TBil, TBA, MPV, PDW and P-LCR gradually elevated in the RG (P<0.05), whilst coagulation factors, ALB, PLT and PA all gradually decreased (P<0.05). The value of area under the curve (AUC) of each coagulation index for early diagnosis of cirrhosis was >0.80, and the sensitivity was >80% (P<0.05). CONCLUSION: Coagulation indexes, coagulation factors, platelet parameters and liver function all effectively reflect the level of liver injury; especially which, coagulation indexes are related to the severity of liver injury, and can provide evidence for the early diagnosis of cirrhosispatients, with clinical significance. AJTR
Authors: Carl-Philipp Hackstein; Lisa Mareike Assmus; Meike Welz; Sabine Klein; Timo Schwandt; Joachim Schultze; Irmgard Förster; Fabian Gondorf; Marc Beyer; Daniela Kroy; Christian Kurts; Jonel Trebicka; Wolfgang Kastenmüller; Percy A Knolle; Zeinab Abdullah Journal: Gut Date: 2016-07-18 Impact factor: 23.059
Authors: Andreas Drolz; Thomas Horvatits; Kevin Roedl; Karoline Rutter; Katharina Staufer; Nikolaus Kneidinger; Ulrike Holzinger; Christian Zauner; Peter Schellongowski; Gottfried Heinz; Thomas Perkmann; Stefan Kluge; Michael Trauner; Valentin Fuhrmann Journal: Hepatology Date: 2016-06-09 Impact factor: 17.425
Authors: P Ramachandran; R Dobie; J R Wilson-Kanamori; E F Dora; B E P Henderson; N T Luu; J R Portman; K P Matchett; M Brice; J A Marwick; R S Taylor; M Efremova; R Vento-Tormo; N O Carragher; T J Kendall; J A Fallowfield; E M Harrison; D J Mole; S J Wigmore; P N Newsome; C J Weston; J P Iredale; F Tacke; J W Pollard; C P Ponting; J C Marioni; S A Teichmann; N C Henderson Journal: Nature Date: 2019-10-09 Impact factor: 49.962