Literature DB >> 34145457

Pertussis Toxin Promotes Pulmonary Hypertension in an Infant Mouse Model of Bordetella pertussis Infection.

Karen M Scanlon1, Ling Chen2, Nicholas H Carbonetti1.   

Abstract

Pertussis, caused by Bordetella pertussis, is a reemerging disease that can produce severe disease manifestations in infants, including pulmonary hypertension (PH). B. pertussis-induced PH is a major risk factor for infection-induced death, but the molecular mechanisms promoting PH are unknown and there is no effective treatment. We examined B. pertussis-induced PH in infant and adult mouse models of pertussis by Fulton index, right heart catheterization, or Doppler echocardiogram. Our results demonstrate that B. pertussis-induced PH is age related and dependent on the expression of pertussis toxin by the bacterium. Hence, pertussis toxin-targeting treatments may ameliorate PH and fatal infant infection.
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  zzm321990 Bordetella pertussis; infant; pertussis toxin; pulmonary hypertension

Mesh：

Substances：

Year:  2022        PMID： 34145457      PMCID： PMC8730479          DOI： 10.1093/infdis/jiab325

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   7.759


  15 in total

Review 1.  The Relationship Between the Right Ventricle and its Load in Pulmonary Hypertension.

Authors:  Anton Vonk Noordegraaf; Berend E Westerhof; Nico Westerhof
Journal:  J Am Coll Cardiol       Date:  2017-01-17       Impact factor: 24.094

2.  Pertussis toxin inhibits negative inotropic and negative chronotropic muscarinic cholinergic effects on the heart.

Authors:  S Tucek; V Dolezal; J Folbergrová; S Hynie; F Kolár; B Ostádal
Journal:  Pflugers Arch       Date:  1987-02       Impact factor: 3.657

Review 3.  Reference ranges and determinants of right ventricle outflow tract acceleration time in healthy adults by two-dimensional echocardiography.

Authors:  Alberto M Marra; Nicola Benjamin; Francesco Ferrara; Olga Vriz; Michele D'Alto; Antonello D'Andrea; Anna Agnese Stanziola; Luna Gargani; Antonio Cittadini; Ekkehard Grünig; Eduardo Bossone
Journal:  Int J Cardiovasc Imaging       Date:  2016-10-06       Impact factor: 2.357

4.  Fatal Pertussis in the Neonatal Mouse Model Is Associated with Pertussis Toxin-Mediated Pathology beyond the Airways.

Authors:  Karen M Scanlon; Yael G Snyder; Ciaran Skerry; Nicholas H Carbonetti
Journal:  Infect Immun       Date:  2017-10-18       Impact factor: 3.441

5.  New mouse model of pulmonary hypertension induced by respiratory syncytial virus bronchiolitis.

Authors:  Dai Kimura; Jordy Saravia; Sridhar Jaligama; Isabella McNamara; Luan D Vu; Ryan D Sullivan; Salvatore Mancarella; Dahui You; Stephania A Cormier
Journal:  Am J Physiol Heart Circ Physiol       Date:  2018-06-15       Impact factor: 4.733

6.  Fatal pulmonary hypertension associated with pertussis in infants: does extracorporeal membrane oxygenation have a role?

Authors:  Natasha B Halasa; Frederick E Barr; Joyce E Johnson; Kathryn M Edwards
Journal:  Pediatrics       Date:  2003-12       Impact factor: 7.124

7.  Clinical value of echocardiographic Doppler-derived right ventricular dp/dt in patients with pulmonary arterial hypertension.

Authors:  Koen Ameloot; Pieter-Jan Palmers; Alexander Vande Bruaene; Annelies Gerits; Werner Budts; Jens-Uwe Voigt; Marion Delcroix
Journal:  Eur Heart J Cardiovasc Imaging       Date:  2014-09-08       Impact factor: 6.875

Review 8.  The Collaborative Pediatric Critical Care Research Network Critical Pertussis Study: collaborative research in pediatric critical care medicine.

Authors:  Jeri S Burr; Tammara L Jenkins; Rick Harrison; Kathleen Meert; K J S Anand; John T Berger; Jerry Zimmerman; Joseph Carcillo; J Michael Dean; Christopher J L Newth; Douglas F Willson; Ronald C Sanders; Murray M Pollack; Eric Harvill; Carol E Nicholson
Journal:  Pediatr Crit Care Med       Date:  2011-07       Impact factor: 3.624

9.  An update of the global burden of pertussis in children younger than 5 years: a modelling study.

Authors:  Karene Hoi Ting Yeung; Philippe Duclos; E Anthony S Nelson; Raymond Christiaan W Hutubessy
Journal:  Lancet Infect Dis       Date:  2017-06-13       Impact factor: 25.071

Review 10.  The right ventricle: interaction with the pulmonary circulation.

Authors:  Michael R Pinsky
Journal:  Crit Care       Date:  2016-09-10       Impact factor: 9.097
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  4 in total

1.  Pertussis toxin suppresses dendritic cell-mediated delivery of B. pertussis into lung-draining lymph nodes.

Authors:  Nela Klimova; Jana Holubova; Gaia Streparola; Jakub Tomala; Ludmila Brazdilova; Ondrej Stanek; Ladislav Bumba; Peter Sebo
Journal:  PLoS Pathog       Date:  2022-06-06       Impact factor: 7.464

Review 2.  The History of Pertussis Toxin.

Authors:  Camille Locht; Rudy Antoine
Journal:  Toxins (Basel)       Date:  2021-09-05       Impact factor: 4.546

Review 3.  Non-primate animal models for pertussis: back to the drawing board?

Authors:  Nevio Cimolai
Journal:  Appl Microbiol Biotechnol       Date:  2022-02-01       Impact factor: 4.813

Review 4.  Novel Strategies to Inhibit Pertussis Toxin.

Authors:  Katharina Ernst
Journal:  Toxins (Basel)       Date:  2022-03-03       Impact factor: 4.546
  4 in total

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