| Literature DB >> 34140474 |
Long Jin1, Qianzi Tang2, Silu Hu1, Zhongxu Chen3, Xuming Zhou4, Bo Zeng1, Yuhao Wang1, Mengnan He1, Yan Li1, Lixuan Gui3, Linyuan Shen1, Keren Long1, Jideng Ma1, Xun Wang1, Zhengli Chen5, Yanzhi Jiang6, Guoqing Tang1, Li Zhu1, Fei Liu7, Bo Zhang8, Zhiqing Huang9, Guisen Li10, Diyan Li1, Vadim N Gladyshev11, Jingdong Yin12, Yiren Gu13, Xuewei Li1, Mingzhou Li14.
Abstract
A comprehensive transcriptomic survey of pigs can provide a mechanistic understanding of tissue specialization processes underlying economically valuable traits and accelerate their use as a biomedical model. Here we characterize four transcript types (lncRNAs, TUCPs, miRNAs, and circRNAs) and protein-coding genes in 31 adult pig tissues and two cell lines. We uncover the transcriptomic variability among 47 skeletal muscles, and six adipose depots linked to their different origins, metabolism, cell composition, physical activity, and mitochondrial pathways. We perform comparative analysis of the transcriptomes of seven tissues from pigs and nine other vertebrates to reveal that evolutionary divergence in transcription potentially contributes to lineage-specific biology. Long-range promoter-enhancer interaction analysis in subcutaneous adipose tissues across species suggests evolutionarily stable transcription patterns likely attributable to redundant enhancers buffering gene expression patterns against perturbations, thereby conferring robustness during speciation. This study can facilitate adoption of the pig as a biomedical model for human biology and disease and uncovers the molecular bases of valuable traits.Entities:
Year: 2021 PMID： 34140474 PMCID： PMC8211698 DOI： 10.1038/s41467-021-23560-8
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919