Yajie Zhang1, Lin Qiao2, Jinxiu Yao3, Nan Yu4, Xiaoping Mu5, Shengqi Huang6, Bo Hu7, Weixuan Li8, Feng Qiu9, Fangyin Zeng10, Cong Chen11, Yuqiu Zhou12, Bashan Zhang13, Tian Cai14, Weijia Wang15, Xianjin Wu16, Yiwen Zhou17, Guochang Wang18, Bo Situ1, Shuling Lan1, Na Li1, Xiu Li1, Zihua Li1, Xin Li1, Congrong Wang1, Chao Yang1, Pingfeng Feng1, Hongxia Wang1, Sijing Zhu19, Yufeng Xiong1, Min Luo1, Wenjuan Shen20, Xiumei Hu21, Lei Zheng22. 1. Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China. 2. Guangdong 999 Brain Hospital, Guangzhou, China. 3. Yangjiang People's Hospital, Yangjiang, China. 4. Zhujiang Hospital, Southern Medical University, Guangzhou, China. 5. Guangdong Women and Children Hospital, Guangzhou, China. 6. Jiangmen Central Hospital, Jiangmen, China. 7. The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. 8. The First People's Hospital of Foshan, Foshan, China. 9. Nanhai Hospital, Southern Medical University, Foshan, China. 10. The Fifth Affiliated Hospital of Southern Medical University, Guangzhou, China. 11. Central People's Hospital of Zhanjiang, Zhanjiang, China. 12. Zhuhai Maternal and Child Health Hospital, Zhuhai, China. 13. Dongguan People's Hospital, Dongguan, China. 14. Nanhai District People's Hospital of Foshan, Foshan, China. 15. Zhongshan People's Hospital, Zhongshan, China. 16. Central People's Hospital of Huizhou, Huizhou, China. 17. Shenzhen Hospital of Southern Medical University, Shenzhen, China. 18. School of Economics, Jinan University, Guangdong, Guangzhou, China. 19. Nanfang College of Sun Yat-Sen University, Guangdong, Guangzhou, China. 20. The Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, Guangdong, China. 21. Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China. hxxm19860108@163.com. 22. Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China. nfyyzhenglei@smu.edu.cn.
Abstract
BACKGROUND: Acute respiratory infections (ARI) cause considerable morbidity and mortality worldwide, especially in children. Unfortunately, there are limited multi-center data on common viral respiratory infections in south China. METHODS: A total of 4403 nasal swabs were collected from children in 10 cities in Guangdong, China in 2019. Seven respiratory viruses, influenza A virus (IFA), influenza B virus (IFB), respiratory syncytial virus (RSV), adenoviruses (ADV) and parainfluenza virus types 1-3 (PIV1, PIV2 and PIV3), were detected by direct immunofluorescence antibody assay. The personal information and clinical characteristics were recorded and analyzed. RESULTS: The results showed that at least one virus was detected in 1099 (24.96 %) samples. The detection rates of RSV, IFA, ADV, PIV3, PIV1 and PIV2 were 7.13 % (314/4403), 5.31 % (234/4403), 4.02 % (177/4403), 3.04 % (134/4403), 1.70 % (75/4403) and 1.16 % (51/4403), respectively. The detection rate of RSV was highest in 0-6-month-old children at 18.18 % (106/583), while the detection rate of IFA was highest in 12-18-year-old children at 20.48 % (17/83). The total detection rates in winter and spring were 35.67 % (219/614) and 34.56 % (403/1166), higher than those in summer, 17.41 % (284/1631), and autumn, 19.46 % (193/992). CONCLUSIONS: RSV and IFA were the main respiratory viruses in children. With increasing age the detection rate of RSV decreased in children, but the trends for the detection rates of IFA and IFB were the opposite. This study provided the viral etiology and epidemiology of pediatric patients with ARI in Guangdong, China.
BACKGROUND:Acute respiratory infections (ARI) cause considerable morbidity and mortality worldwide, especially in children. Unfortunately, there are limited multi-center data on common viral respiratory infections in south China. METHODS: A total of 4403 nasal swabs were collected from children in 10 cities in Guangdong, China in 2019. Seven respiratory viruses, influenza A virus (IFA), influenza B virus (IFB), respiratory syncytial virus (RSV), adenoviruses (ADV) and parainfluenza virus types 1-3 (PIV1, PIV2 and PIV3), were detected by direct immunofluorescence antibody assay. The personal information and clinical characteristics were recorded and analyzed. RESULTS: The results showed that at least one virus was detected in 1099 (24.96 %) samples. The detection rates of RSV, IFA, ADV, PIV3, PIV1 and PIV2 were 7.13 % (314/4403), 5.31 % (234/4403), 4.02 % (177/4403), 3.04 % (134/4403), 1.70 % (75/4403) and 1.16 % (51/4403), respectively. The detection rate of RSV was highest in 0-6-month-old children at 18.18 % (106/583), while the detection rate of IFA was highest in 12-18-year-old children at 20.48 % (17/83). The total detection rates in winter and spring were 35.67 % (219/614) and 34.56 % (403/1166), higher than those in summer, 17.41 % (284/1631), and autumn, 19.46 % (193/992). CONCLUSIONS:RSV and IFA were the main respiratory viruses in children. With increasing age the detection rate of RSV decreased in children, but the trends for the detection rates of IFA and IFB were the opposite. This study provided the viral etiology and epidemiology of pediatric patients with ARI in Guangdong, China.