| Literature DB >> 34139761 |
Arnau Casanovas-Massana1, Daiana de Oliveira2, Andrew G Schneider1, Mike Begon3, James E Childs1, Federico Costa1,2,4, Mitermayer G Reis1,2, Albert I Ko1,2, Elsio A Wunder1,2.
Abstract
In this study, we genotyped samples from environmental reservoirs (surface water and soil), colonized rat specimens, and cases of human severe leptospirosis from an endemic urban slum in Brazil, to determine the molecular epidemiology of pathogenic Leptospira and identify pathways of leptospirosis infection. We identified a well-established population of Leptospira interrogans serovar Copenhageni common to human leptospirosis cases, and animal and environmental reservoirs. This finding provides genetic evidence for a potential environmental spillover pathway for rat-borne leptospirosis through the environment in this urban community and highlights the importance of environmental and social interventions to reduce spillover infections.Entities:
Keywords: zzm321990 Leptospira interroganszzm321990 ; zzm321990 Rattus norvegicuszzm321990 ; environmental reservoir; genotyping; leptospirosis; pathogenic Leptospira; soil; water
Mesh：
Year: 2022 PMID： 34139761 PMCID： PMC8730487 DOI： 10.1093/infdis/jiab323
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 7.759