Andrea Giacomelli1, Alessandro Cozzi-Lepri2, Antonella Cingolani3, Alessandro Tavelli4, Valentina Mazzotta5, Daniele Tesoro6, Matteo Bassetti7, Antonella Castagna8, Antonio Di Biagio7, Miriam Lichter9, Antonella d'Arminio Monforte6, Stefano Rusconi1,10. 1. III Infectious Diseases Unit, ASST-FBF-Sacco, Department of Biomedical and Clinical Sciences DIBIC Luigi Sacco, Università di Milano, Milan, Italy. 2. Centre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME), Institute for Global Health, UCL, London, United Kingdom. 3. Infectious Diseases Unit, Fondazione Policlinico Universitario A. Gemelli-Università Cattolica Del Sacro Cuore, Rome, Italy. 4. ICONA Foundation, Milan, Italy. 5. HIV/AIDS Unit, INMI "Lazzaro Spallanzani" IRCCS, Rome, Italy. 6. Clinic of Infectious and Tropical Diseases, ASST Santi Paolo e Carlo, University of Milan Department of Health Sciences, Milan, Italy. 7. Infectious Diseases Clinic, Policlinico San Martino Hospital, Department of Health Sciences, University of Genoa, Genova, Italy. 8. Infectious Diseases, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy. 9. Infectious Diseases Unit, Sapienza University of Rome, Santa Maria Goretti Hospital, Latina, Italy; and. 10. Currently, UOC Malattie Infettive, ASST Ovest Milanese, Ospedale di Legnano, Italy.
Abstract
BACKGROUND: To assess the impact of syphilis infection on the risk of HIV-RNA elevation in people living with HIV (PLWH) with current HIV-RNA ≤50 copies/mL. SETTING: The Italian Cohort Naive Antiretrovirals. METHODS: All PLWH (2009-2020) under antiretroviral treatment with at least 2 consecutive HIV-RNA values ≤50 copies/mL before the date of syphilis diagnosis and at least 1 HIV-RNA determination after the syphilis event were enrolled. A control group of PLWH without syphilis was matched for mode of HIV transmission. Outcomes were defined using the first HIV-RNA measure in the time window ranging between -2 and +6 months of the diagnosis/index date. The primary outcome used a single value >200 copies/mL to define HIV-RNA elevation associated with risk of transmission. The association between syphilis infection and the protocol defined outcome was evaluated using logistic regression analysis. RESULTS: Nine hundred twenty-six PLWH with a syphilis event were enrolled and matched with a random sample of 1370 PLWH without syphilis. Eighteen of the 926 (1.9%) with syphilis had ≥1 HIV-RNA >200 copies/mL in the window vs. 29/1370 (2.1%) of the not exposed (P = 0.77). In the multivariable analysis adjusted for age, year of diagnosis/index date, and clinical site, syphilis infection was not associated with the risk of HIV-RNA >200 copies/mL (adjusted odds ratio 0.81; 95% confidence interval 0.43-1.52, P = 0.508). CONCLUSIONS: We did not find any evidence for an association between syphilis infection and viral elevation >200 copies/mL.
BACKGROUND: To assess the impact of syphilis infection on the risk of HIV-RNA elevation in people living with HIV (PLWH) with current HIV-RNA ≤50 copies/mL. SETTING: The Italian Cohort Naive Antiretrovirals. METHODS: All PLWH (2009-2020) under antiretroviral treatment with at least 2 consecutive HIV-RNA values ≤50 copies/mL before the date of syphilis diagnosis and at least 1 HIV-RNA determination after the syphilis event were enrolled. A control group of PLWH without syphilis was matched for mode of HIV transmission. Outcomes were defined using the first HIV-RNA measure in the time window ranging between -2 and +6 months of the diagnosis/index date. The primary outcome used a single value >200 copies/mL to define HIV-RNA elevation associated with risk of transmission. The association between syphilis infection and the protocol defined outcome was evaluated using logistic regression analysis. RESULTS: Nine hundred twenty-six PLWH with a syphilis event were enrolled and matched with a random sample of 1370 PLWH without syphilis. Eighteen of the 926 (1.9%) with syphilis had ≥1 HIV-RNA >200 copies/mL in the window vs. 29/1370 (2.1%) of the not exposed (P = 0.77). In the multivariable analysis adjusted for age, year of diagnosis/index date, and clinical site, syphilis infection was not associated with the risk of HIV-RNA >200 copies/mL (adjusted odds ratio 0.81; 95% confidence interval 0.43-1.52, P = 0.508). CONCLUSIONS: We did not find any evidence for an association between syphilis infection and viral elevation >200 copies/mL.
Authors: Timothy W Menza; Stephen A Berry; Julie Dombrowski; Edward Cachay; Jodie Dionne-Odom; Katerina Christopoulos; Heidi M Crane; Mari M Kitahata; Kenneth H Mayer Journal: Clin Infect Dis Date: 2022-08-31 Impact factor: 20.999
Authors: Thomas Lemmet; Laurent Cotte; Clotilde Allavena; Thomas Huleux; Claudine Duvivier; Hélène Laroche; André Cabie; Pascal Pugliese; Thomas Jovelin; Marine Maurel; Cyrille Delpierre; David Rey Journal: PLoS One Date: 2022-05-19 Impact factor: 3.240