Literature DB >> 34137665

Pharmacogenomics education, research and clinical implementation in the state of Minnesota.

Jeffrey R Bishop1,2, R Stephanie Huang1, Jacob T Brown3, Pawel Mroz4, Steven G Johnson5, Josiah D Allen6,7, Suzette J Bielinski8, Julie England9, Joel F Farley10, David Gregornik11, Jyothsna Giri12, Christine Kroger13, Susie E Long14, Tiana Luczak3,15, Erin J McGonagle1, Sisi Ma5, Eric T Matey16, Pinar K Mandic17, Ann M Moyer18, Wayne T Nicholson19, Natasha Petry20,21, Pamala A Pawloski22, Allyson Schlichte23, Stephen W Schondelmeyer10, Randall D Seifert3, Marilyn K Speedie24, David Stenehjem3, Robert J Straka1, Jason Wachtl25, Stephen C Waring26, Brian Van Ness27, Heather A Zierhut27, Constantin Aliferis5, Susan M Wolf28, Catherine A McCarty29, Pamala A Jacobson1.   

Abstract

Several healthcare organizations across Minnesota have developed formal pharmacogenomic (PGx) clinical programs to increase drug safety and effectiveness. Healthcare professional and student education is strong and there are multiple opportunities in the state for learners to gain workforce skills and develop advanced competency in PGx. Implementation planning is occurring at several organizations and others have incorporated structured utilization of PGx into routine workflows. Laboratory-based and translational PGx research in Minnesota has driven important discoveries in several therapeutic areas. This article reviews the state of PGx activities in Minnesota including educational programs, research, national consortia involvement, technology, clinical implementation and utilization and reimbursement, and outlines the challenges and opportunities in equitable implementation of these advances.

Entities:  

Keywords:  Minnesota; implementation; pharmacogenomics

Mesh:

Year:  2021        PMID: 34137665      PMCID: PMC8265281          DOI: 10.2217/pgs-2021-0058

Source DB:  PubMed          Journal:  Pharmacogenomics        ISSN: 1462-2416            Impact factor:   2.638


  23 in total

1.  Implementation of wide-scale pharmacogenetic testing in primary care.

Authors:  Jordan Baye; Aissa Aifaoui; Russell A Wilke; Roxana A Lupu; John Savageau; Britni Gapp; Amanda Massmann; Deidre Hahn; Catherine Hajek; April Schultz
Journal:  Pharmacogenomics       Date:  2019-08       Impact factor: 2.533

2.  Quantitation of dihydropyrimidine dehydrogenase expression by real-time reverse transcription polymerase chain reaction.

Authors:  M R Johnson; K Wang; J B Smith; M J Heslin; R B Diasio
Journal:  Anal Biochem       Date:  2000-02-15       Impact factor: 3.365

3.  Profound dihydropyrimidine dehydrogenase deficiency resulting from a novel compound heterozygote genotype.

Authors:  Martin R Johnson; Kangsheng Wang; Robert B Diasio
Journal:  Clin Cancer Res       Date:  2002-03       Impact factor: 12.531

Review 4.  Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response.

Authors:  M P Goetz; A Kamal; M M Ames
Journal:  Clin Pharmacol Ther       Date:  2007-09-19       Impact factor: 6.875

5.  Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism.

Authors:  L Lennard; J A Van Loon; R M Weinshilboum
Journal:  Clin Pharmacol Ther       Date:  1989-08       Impact factor: 6.875

6.  Genetic variation among 82 pharmacogenes: The PGRNseq data from the eMERGE network.

Authors:  W S Bush; D R Crosslin; A Owusu-Obeng; J Wallace; B Almoguera; M A Basford; S J Bielinski; D S Carrell; J J Connolly; D Crawford; K F Doheny; C J Gallego; A S Gordon; B Keating; J Kirby; T Kitchner; S Manzi; A R Mejia; V Pan; C L Perry; J F Peterson; C A Prows; J Ralston; S A Scott; A Scrol; M Smith; S C Stallings; T Veldhuizen; W Wolf; S Volpi; K Wiley; R Li; T Manolio; E Bottinger; M H Brilliant; D Carey; R L Chisholm; C G Chute; J L Haines; H Hakonarson; J B Harley; I A Holm; I J Kullo; G P Jarvik; E B Larson; C A McCarty; M S Williams; J C Denny; L J Rasmussen-Torvik; D M Roden; M D Ritchie
Journal:  Clin Pharmacol Ther       Date:  2016-06-01       Impact factor: 6.875

7.  Identification of genetic variants associated with tacrolimus metabolism in kidney transplant recipients by extreme phenotype sampling and next generation sequencing.

Authors:  Casey R Dorr; Baolin Wu; Rory P Remmel; Amutha Muthusamy; David P Schladt; Juan E Abrahante; Weihua Guan; Roslyn B Mannon; Arthur J Matas; William S Oetting; Pamala A Jacobson; Ajay K Israni
Journal:  Pharmacogenomics J       Date:  2018-11-16       Impact factor: 3.550

8.  Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing.

Authors:  Larisa H Cavallari; Sara L Van Driest; Cynthia A Prows; Jeffrey R Bishop; Nita A Limdi; Victoria M Pratt; Laura B Ramsey; D Max Smith; Sony Tuteja; Benjamin Q Duong; J Kevin Hicks; James C Lee; Aniwaa Owusu Obeng; Amber L Beitelshees; Gillian C Bell; Kathryn Blake; Daniel J Crona; Lynn Dressler; Ryan A Gregg; Lindsay J Hines; Stuart A Scott; Richard C Shelton; Kristin Wiisanen Weitzel; Julie A Johnson; Josh F Peterson; Philip E Empey; Todd C Skaar
Journal:  Genet Med       Date:  2019-03-21       Impact factor: 8.822

9.  Next-Generation Sequencing of CYP2C19 in Stent Thrombosis: Implications for Clopidogrel Pharmacogenomics.

Authors:  Joel A Morales-Rosado; Kashish Goel; Lingxin Zhang; Axel Åkerblom; Saurabh Baheti; John L Black; Niclas Eriksson; Lars Wallentin; Stefan James; Robert F Storey; Shaun G Goodman; Gregory D Jenkins; Bruce W Eckloff; Suzette J Bielinski; Hugues Sicotte; Stephen Johnson; Veronique L Roger; Liewei Wang; Richard Weinshilboum; Eric W Klee; Charanjit S Rihal; Naveen L Pereira
Journal:  Cardiovasc Drugs Ther       Date:  2021-06       Impact factor: 3.947

10.  Genotype-guided tacrolimus dosing in African-American kidney transplant recipients.

Authors:  K Sanghavi; R C Brundage; M B Miller; D P Schladt; A K Israni; W Guan; W S Oetting; R B Mannon; R P Remmel; A J Matas; P A Jacobson
Journal:  Pharmacogenomics J       Date:  2015-12-15       Impact factor: 3.550

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  3 in total

1.  The Value of Pharmacogenetics to Reduce Drug-Related Toxicity in Cancer Patients.

Authors:  Doreen Z Mhandire; Andrew K L Goey
Journal:  Mol Diagn Ther       Date:  2022-02-03       Impact factor: 4.074

2.  Characterizing pharmacogenetic programs using the consolidated framework for implementation research: A structured scoping review.

Authors:  John H McDermott; Stuart Wright; Videha Sharma; William G Newman; Katherine Payne; Paul Wilson
Journal:  Front Med (Lausanne)       Date:  2022-08-18

Review 3.  A Scoping Review of Attitudes and Experiences with Pharmacogenomic Testing among Patients and the General Public: Implications for Patient Counseling.

Authors:  Josiah D Allen; Amy L Pittenger; Jeffrey R Bishop
Journal:  J Pers Med       Date:  2022-03-09
  3 in total

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