| Literature DB >> 34137582 |
Zeyu Li1, Jiatong Ni1, Liping Liu2, Liyuan Gu3, Zhiguang Wu4, Tianlong Li4, Krasnyuk Ivan Ivanovich4, Wancheng Zhao1, Tiedong Sun1, Ting Wang1.
Abstract
We demonstrate a versatile nanoparticle with imaging-guided chemo-photothermal synergistic therapy and EpCAM-targeted delivery of liver tumor cells. EpCAM antibody (anti-EpCAM) and Pt(IV) were grafted onto the polydopamine carbon dots (PDA-CDs) by the amidation reaction. The EpCAM antibody of particles enables the targeted interaction with liver progenitor cells due to their overexpressed EpCAM protein. The tetravalent platinum prodrug [Pt(IV)] induces apoptosis with minimum toxic side effects through the interaction between cisplatin and tumor cell DNA. The nanoparticles displayed stable photothermal property and considerable anti-tumor therapeutic effect in vivo. Coupling with cellular imaging due to their fluorescence property, anti-EpCAM@PDA-CDs@Pt(IV) offers a convenient and effective platform for imaging-guided chemo-photothermal synergistic therapy toward liver cancers in the near future.Entities:
Keywords: cancer therapy; chemo−photothermal synergistic therapy; fluorescence imaging; imaging guiding; polydopamine-based carbon dots; tumor-targeted delivery
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Year: 2021 PMID： 34137582 DOI： 10.1021/acsami.1c05079
Source DB: PubMed Journal: ACS Appl Mater Interfaces ISSN： 1944-8244 Impact factor: 9.229