Literature DB >> 34137022

Generalization of a genetic risk score for time to first albuminuria in children with sickle cell anaemia: SCCRIP cohort study results.

Sara R Rashkin1,2, Evadnie Rampersaud1, Guolian Kang3, Kenneth I Ataga4, Jane S Hankins2, Winfred Wang2, Jeremie H Estepp2,5, Mitchell J Weiss2, Jeffrey Lebensburger6, Rima S Zahr7.   

Abstract

Albuminuria predicts kidney disease progression in individuals with sickle cell anaemia (SCA); however, earlier prediction of kidney disease with introduction of reno-protective therapies prior to the onset of albuminuria may attenuate disease progression. A genetic risk score (GRS) for SCA-related nephropathy may provide an improved one-time test for early identification of high-risk patients. We utilized a GRS from a recent, large, trans-ethnic meta-analysis to identify three single nucleotide polymorphisms that associate individually and in a GRS with time to first albuminuria episode in children with SCA.
© 2021 British Society for Haematology and John Wiley & Sons Ltd.

Entities:  

Keywords:  albuminuria; genetic risk score; sickle cell anaemia

Mesh：

Year:  2021        PMID： 34137022      PMCID： PMC8282691          DOI： 10.1111/bjh.17647

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   8.615


  14 in total

1.  APOL1, α-thalassemia, and BCL11A variants as a genetic risk profile for progression of chronic kidney disease in sickle cell anemia.

Authors:  Santosh L Saraf; Binal N Shah; Xu Zhang; Jin Han; Bamidele O Tayo; Taimur Abbasi; Adam Ostrower; Elizabeth Guzman; Robert E Molokie; Michel Gowhari; Johara Hassan; Shivi Jain; Richard S Cooper; Roberto F Machado; James P Lash; Victor R Gordeuk
Journal:  Haematologica       Date:  2016-09-22       Impact factor: 9.941

2.  Roles of APOL1 G1 and G2 variants in sickle cell disease patients: kidney is the main target.

Authors:  Raphaël Kormann; Anne-Sophie Jannot; Céline Narjoz; Jean-Antoine Ribeil; Sandra Manceau; Marianne Delville; Valentin Joste; Dominique Prié; Jacques Pouchot; Eric Thervet; Marie Courbebaisse; Jean-Benoît Arlet
Journal:  Br J Haematol       Date:  2017-07-12       Impact factor: 6.998

3.  Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking.

Authors:  Peter Knauth; Thomas Schlüter; Martin Czubayko; Cornelia Kirsch; Volker Florian; Susan Schreckenberger; Heidi Hahn; Ralf Bohnensack
Journal:  J Mol Biol       Date:  2005-04-08       Impact factor: 5.469

4.  APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases.

Authors:  Opeyemi A Olabisi; Jia-Yue Zhang; Lynn VerPlank; Nathan Zahler; Salvatore DiBartolo; John F Heneghan; Johannes S Schlöndorff; Jung Hee Suh; Paul Yan; Seth L Alper; David J Friedman; Martin R Pollak
Journal:  Proc Natl Acad Sci U S A       Date:  2015-12-23       Impact factor: 11.205

5.  Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study.

Authors:  Afshin Parsa; Peter A Kanetsky; Rui Xiao; Jayanta Gupta; Nandita Mitra; Sophie Limou; Dawei Xie; Huichun Xu; Amanda Hyre Anderson; Akinlolu Ojo; John W Kusek; Claudia M Lora; L Lee Hamm; Jiang He; Niina Sandholm; Janina Jeff; Dominic E Raj; Carsten A Böger; Erwin Bottinger; Shabnam Salimi; Rulan S Parekh; Sharon G Adler; Carl D Langefeld; Donald W Bowden; Per-Henrik Groop; Carol Forsblom; Barry I Freedman; Michael Lipkowitz; Caroline S Fox; Cheryl A Winkler; Harold I Feldman
Journal:  J Am Soc Nephrol       Date:  2016-10-11       Impact factor: 10.121

6.  Hydroxyurea prevents onset and progression of albuminuria in children with sickle cell anemia.

Authors:  Rima S Zahr; Jane S Hankins; Guolian Kang; Chen Li; Winfred C Wang; Jeffrey Lebensburger; Jeremie H Estepp
Journal:  Am J Hematol       Date:  2018-11-29       Impact factor: 10.047

7.  High one year mortality in adults with sickle cell disease and end-stage renal disease.

Authors:  Ann C McClellan; Jean-Christophe Luthi; Janet R Lynch; J Michael Soucie; Roshni Kulkarni; Antonio Guasch; Edwin D Huff; David Gilbertson; William M McClellan; Michael R DeBaun
Journal:  Br J Haematol       Date:  2012-09-12       Impact factor: 6.998

Review 8.  The glomerulopathy of sickle cell disease.

Authors:  Kenneth I Ataga; Vimal K Derebail; David R Archer
Journal:  Am J Hematol       Date:  2014-06-19       Impact factor: 10.047

9.  Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

Authors:  Alexander Teumer; Yong Li; Sahar Ghasemi; Bram P Prins; Matthias Wuttke; Tobias Hermle; Ayush Giri; Karsten B Sieber; Chengxiang Qiu; Holger Kirsten; Adrienne Tin; Audrey Y Chu; Nisha Bansal; Mary F Feitosa; Lihua Wang; Jin-Fang Chai; Massimiliano Cocca; Christian Fuchsberger; Mathias Gorski; Anselm Hoppmann; Katrin Horn; Man Li; Jonathan Marten; Damia Noce; Teresa Nutile; Sanaz Sedaghat; Gardar Sveinbjornsson; Bamidele O Tayo; Peter J van der Most; Yizhe Xu; Zhi Yu; Lea Gerstner; Johan Ärnlöv; Stephan J L Bakker; Daniela Baptista; Mary L Biggs; Eric Boerwinkle; Hermann Brenner; Ralph Burkhardt; Robert J Carroll; Miao-Li Chee; Miao-Ling Chee; Mengmeng Chen; Ching-Yu Cheng; James P Cook; Josef Coresh; Tanguy Corre; John Danesh; Martin H de Borst; Alessandro De Grandi; Renée de Mutsert; Aiko P J de Vries; Frauke Degenhardt; Katalin Dittrich; Jasmin Divers; Kai-Uwe Eckardt; Georg Ehret; Karlhans Endlich; Janine F Felix; Oscar H Franco; Andre Franke; Barry I Freedman; Sandra Freitag-Wolf; Ron T Gansevoort; Vilmantas Giedraitis; Martin Gögele; Franziska Grundner-Culemann; Daniel F Gudbjartsson; Vilmundur Gudnason; Pavel Hamet; Tamara B Harris; Andrew A Hicks; Hilma Holm; Valencia Hui Xian Foo; Shih-Jen Hwang; M Arfan Ikram; Erik Ingelsson; Vincent W V Jaddoe; Johanna Jakobsdottir; Navya Shilpa Josyula; Bettina Jung; Mika Kähönen; Chiea-Chuen Khor; Wieland Kiess; Wolfgang Koenig; Antje Körner; Peter Kovacs; Holly Kramer; Bernhard K Krämer; Florian Kronenberg; Leslie A Lange; Carl D Langefeld; Jeannette Jen-Mai Lee; Terho Lehtimäki; Wolfgang Lieb; Su-Chi Lim; Lars Lind; Cecilia M Lindgren; Jianjun Liu; Markus Loeffler; Leo-Pekka Lyytikäinen; Anubha Mahajan; Joseph C Maranville; Deborah Mascalzoni; Barbara McMullen; Christa Meisinger; Thomas Meitinger; Kozeta Miliku; Dennis O Mook-Kanamori; Martina Müller-Nurasyid; Josyf C Mychaleckyj; Matthias Nauck; Kjell Nikus; Boting Ning; Raymond Noordam; Jeffrey O' Connell; Isleifur Olafsson; Nicholette D Palmer; Annette Peters; Anna I Podgornaia; Belen Ponte; Tanja Poulain; Peter P Pramstaller; Ton J Rabelink; Laura M Raffield; Dermot F Reilly; Rainer Rettig; Myriam Rheinberger; Kenneth M Rice; Fernando Rivadeneira; Heiko Runz; Kathleen A Ryan; Charumathi Sabanayagam; Kai-Uwe Saum; Ben Schöttker; Christian M Shaffer; Yuan Shi; Albert V Smith; Konstantin Strauch; Michael Stumvoll; Benjamin B Sun; Silke Szymczak; E-Shyong Tai; Nicholas Y Q Tan; Kent D Taylor; Andrej Teren; Yih-Chung Tham; Joachim Thiery; Chris H L Thio; Hauke Thomsen; Unnur Thorsteinsdottir; Anke Tönjes; Johanne Tremblay; André G Uitterlinden; Pim van der Harst; Niek Verweij; Suzanne Vogelezang; Uwe Völker; Melanie Waldenberger; Chaolong Wang; Otis D Wilson; Charlene Wong; Tien-Yin Wong; Qiong Yang; Masayuki Yasuda; Shreeram Akilesh; Murielle Bochud; Carsten A Böger; Olivier Devuyst; Todd L Edwards; Kevin Ho; Andrew P Morris; Afshin Parsa; Sarah A Pendergrass; Bruce M Psaty; Jerome I Rotter; Kari Stefansson; James G Wilson; Katalin Susztak; Harold Snieder; Iris M Heid; Markus Scholz; Adam S Butterworth; Adriana M Hung; Cristian Pattaro; Anna Köttgen
Journal:  Nat Commun       Date:  2019-09-11       Impact factor: 17.694

10.  Albuminuria Is Associated with Endothelial Dysfunction and Elevated Plasma Endothelin-1 in Sickle Cell Anemia.

Authors:  Kenneth I Ataga; Vimal K Derebail; Melissa Caughey; Laila Elsherif; Jessica H Shen; Susan K Jones; Poulami Maitra; David M Pollock; Jianwen Cai; David R Archer; Alan L Hinderliter
Journal:  PLoS One       Date:  2016-09-26       Impact factor: 3.240
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