| Literature DB >> 34135334 |
Fernando Colchero1,2, Susan C Alberts3,4,5, José Manuel Aburto6,7,8, Elizabeth A Archie9,10, Christophe Boesch11,12, Thomas Breuer13,14, Fernando A Campos15, Anthony Collins16, Dalia A Conde6,17,18, Marina Cords19,20, Catherine Crockford11,12, Melissa Emery Thompson21,22, Linda M Fedigan23, Claudia Fichtel24, Milou Groenenberg13,25, Catherine Hobaiter26,27, Peter M Kappeler24,28, Richard R Lawler29, Rebecca J Lewis30,31, Zarin P Machanda22,32, Marie L Manguette11,13, Martin N Muller21,22, Craig Packer33, Richard J Parnell13, Susan Perry34, Anne E Pusey35, Martha M Robbins11, Robert M Seyfarth36, Joan B Silk37, Johanna Staerk6,17,18, Tara S Stoinski38, Emma J Stokes39, Karen B Strier40, Shirley C Strum41,42,43,44, Jenny Tung35,45,46, Francisco Villavicencio47, Roman M Wittig11,12, Richard W Wrangham22,48, Klaus Zuberbühler26,27,49, James W Vaupel6,46.
Abstract
Is it possible to slow the rate of ageing, or do biological constraints limit its plasticity? We test the 'invariant rate of ageing' hypothesis, which posits that the rate of ageing is relatively fixed within species, with a collection of 39 human and nonhuman primate datasets across seven genera. We first recapitulate, in nonhuman primates, the highly regular relationship between life expectancy and lifespan equality seen in humans. We next demonstrate that variation in the rate of ageing within genera is orders of magnitude smaller than variation in pre-adult and age-independent mortality. Finally, we demonstrate that changes in the rate of ageing, but not other mortality parameters, produce striking, species-atypical changes in mortality patterns. Our results support the invariant rate of ageing hypothesis, implying biological constraints on how much the human rate of ageing can be slowed.Entities:
Mesh：
Year: 2021 PMID： 34135334 DOI： 10.1038/s41467-021-23894-3
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919