| Literature DB >> 34132051 |
Yanan Yu1,2,3,4, Meihua Wu1,2,3,4, Xinxin Cui1,2,3,4, Fengxiang Xu1,2,3,4, Feng Wen5, Liangqi Pan1,2,3,4, Shuo Li1,2,3,4, Huapeng Sun1,2,3,4, Xuhui Zhu1,2,3,4, Jiate Lin1,2,3,4, Yaling Feng1,2,3,4, Mingliang Li1,2,3,4, Yang Liu1,2,3,4, Shaohua Yuan1,2,3,4, Ming Liao1,2,3,4, Hailiang Sun1,2,3,4.
Abstract
Swine are considered as 'mixing vessels' of influenza A viruses and play an important role in the generation of novel influenza pandemics. In this study, we described that the H3N2 swine influenza (swH3N2) viruses currently circulating in pigs in Guangdong province carried six internal genes from 2009 pandemic H1N1 virus (pmd09), and their antigenicity was obviously different from that of current human H3N2 influenza viruses or recommended vaccine strains (A/Guangdong/1194/2019, A/Hong Kong/4801/2014). These swH3N2 viruses preferentially bonded to the human-like receptors, and efficiently replicated in human, canine and swine cells. In addition, the virus replicated in turbinate and trachea of guinea pigs, and efficiently transmitted among guinea pigs, and virus shedding last for 6 days post-infection (dpi). The virus replicated in the respiratory tract of pigs, effectively transmitted among pigs, and virus shedding last until 9 dpi. Taken together, these current swH3N2 viruses might have the zoonotic potential. Strengthening surveillance and monitoring the pathogenicity of such swH3N2 viruses are urgently needed.Entities:
Keywords: H3N2 influenza virus; antigenicity; pathogenicity; receptor binding feature; replication
Mesh：
Year: 2021 PMID： 34132051 DOI： 10.1111/tbed.14190
Source DB: PubMed Journal: Transbound Emerg Dis ISSN： 1865-1674 Impact factor: 4.521