Bin Zhu1, Xiaokai Feng2, Chunguo Jiang2, Song Mi2, Liya Yang3, Zhigang Zhao4, Yong Zhang5, Liming Zhang6. 1. Department of pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100160, China. 2. Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China. 3. Cranio-maxillo-facial Surgery Department, Plastic Surgery Hospital of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100144, China. 4. Department of pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100160, China. 1022zzg@sina.com. 5. Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. mailzhangyong@126.com. 6. Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China. zhangliming@bjcyh.com.
Abstract
BACKGROUND: Coronavirus disease-19 (COVID-19) has become a world health threaten. Its risk factors with death were still not known. White blood cells (WBC) count as a reflection of inflammation has played a vital role in COVID-19, however its level with death is not yet investigated. METHODS: In this retrospective, single-center study, all confirmed patients with COVID-19 at West Branch of Union Hospital from Jan 29 to Feb 28, 2020 were collected and analyzed. Demographic and clinical data including laboratory examinations were analyzed and compared between recovery and death patients. RESULTS: A total of 163 patients including 33 death cases were included in this study. Significant association was found between WBC count and death (HR = 1.14, 95%CI: 1.09-1.20, p < 0.001). The regression analysis results showed there was a significant association between WBC count and death (HR = 5.72, 95%CI: 2.21-14.82, p < 0.001) when use the second quartile as a cutoff value (> 6.16 × 10^9/L). The difference was still exist after adjusting for confounding factors (HR = 6.26, 95%CI: 1.72-22.77, p = 0.005). In addition, Kaplan-meier survival analysis showed that there was a significant decline of the cumulative survival rate (p < 0.001) in those with WBC count ≥6.16 × 10^9/L. CONCLUSION: WBC count at admission is significantly corelated with death in COVID-19 patients. Higher level of WBC count should be given more attention in the treatment of COVID-19.
BACKGROUND:Coronavirus disease-19 (COVID-19) has become a world health threaten. Its risk factors with death were still not known. White blood cells (WBC) count as a reflection of inflammation has played a vital role in COVID-19, however its level with death is not yet investigated. METHODS: In this retrospective, single-center study, all confirmed patients with COVID-19 at West Branch of Union Hospital from Jan 29 to Feb 28, 2020 were collected and analyzed. Demographic and clinical data including laboratory examinations were analyzed and compared between recovery and deathpatients. RESULTS: A total of 163 patients including 33 death cases were included in this study. Significant association was found between WBC count and death (HR = 1.14, 95%CI: 1.09-1.20, p < 0.001). The regression analysis results showed there was a significant association between WBC count and death (HR = 5.72, 95%CI: 2.21-14.82, p < 0.001) when use the second quartile as a cutoff value (> 6.16 × 10^9/L). The difference was still exist after adjusting for confounding factors (HR = 6.26, 95%CI: 1.72-22.77, p = 0.005). In addition, Kaplan-meier survival analysis showed that there was a significant decline of the cumulative survival rate (p < 0.001) in those with WBC count ≥6.16 × 10^9/L. CONCLUSION: WBC count at admission is significantly corelated with death in COVID-19patients. Higher level of WBC count should be given more attention in the treatment of COVID-19.
Entities:
Keywords:
Coronavirus disease-19; Death; Second quartile; Survival rate; White blood cells
Authors: Soedarsono Soedarsono; Deri Yunita; Emma Ayu Lirani; Robitha Kartika Sari; Yoga Indrawan Pratama; Afifah Listiati; Bambang Supriyanto Journal: Int J Gen Med Date: 2022-06-30
Authors: Basmah M Azad Allarakia; Hattan S Gattan; Rawan H Abdeen; Bassam M Al-Ahmadi; Abdullah F Shater; Mohammed B Bazaid; Omar W Althomali; Abdulrahman S Bazaid Journal: Dis Markers Date: 2022-05-26 Impact factor: 3.464