| Literature DB >> 34126459 |
Bhagyalalitha Meduri1, Gurubasavaraj Veeranna Pujar2, T Durai Ananda Kumar1, H S Akshatha1, Arun Kumar Sethu1, Manisha Singh1, Abhinav Kanagarla3, Bijo Mathew4.
Abstract
Lysophosphatidic acid (LPA) activates six LPA receptors (LPAR1-6) and regulates various cellular activities such as cell proliferation, cytoprotection, and wound healing. Many studies elucidated the pathological outcomes of LPA are due to the alteration in signaling pathways, which include migration and invasion of cancer cells, fibrosis, atherosclerosis, and inflammation. Current pathophysiological research on LPA and its receptors provides a means that LPA receptors are new therapeutic targets for disorders associated with LPA. Various chemical modulators are developed and are under investigation to treat a wide range of pathological complications. This review summarizes the physiological and pathological roles of LPA signaling, development of various LPA modulators, their structural features, patents, and their clinical outcomes.Entities:
Keywords: Endothelial differentiating gene; G-protein coupled receptors; Invasion; LPA modulators; Lysophosphatidic acid; Lysophospholipase D; Migration; Proliferation
Year: 2021 PMID： 34126459 DOI： 10.1016/j.ejmech.2021.113574
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514