Tomas R Burke1,2, Peter K F Addison1,3, Carlos E Pavesio1,3. 1. Uveitis Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK. 2. Uveitis and Medical Retina Service, Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, UK. 3. NIHR Biomedical Research Centre at Moorfields and UCL, Institute of Ophthalmology, London, UK.
Abstract
Purpose: To present the observation of multifocal evanescent white dot syndrome (MEWDS)-like phenotypes developing in association with the onset of choroidal neovascularization (CNV) in a series of patients. Methods: Patients presenting to tertiary-care centers with MEWDS-like phenotypes and CNV were identified. Results: Five patients presented for the management of CNV in the context of previous diagnoses of punctate inner choroidopathy (PIC) and/or myopia. In time-periods ranging from 0 days to 12 weeks from the diagnosis of active CNV, MEWDS-like changes were observed. Treatment with anti-VEGF agents were instituted in four cases, in an as-required protocol. 1 patient received systemic steroid.Conclusions: The development of MEWDS-like phenotypes in association with CNVM can occur in eyes with either inflammatory or non-inflammatory CNVM, and in those who were or were not treated with anti-VEGF therapy. The association suggests an inflammatory event, which causes RPE changes and probably induces the development of the CNV.
Purpose: To present the observation of multifocal evanescent white dot syndrome (MEWDS)-like phenotypes developing in association with the onset of choroidal neovascularization (CNV) in a series of patients. Methods:Patients presenting to tertiary-care centers with MEWDS-like phenotypes and CNV were identified. Results: Five patients presented for the management of CNV in the context of previous diagnoses of punctate inner choroidopathy (PIC) and/or myopia. In time-periods ranging from 0 days to 12 weeks from the diagnosis of active CNV, MEWDS-like changes were observed. Treatment with anti-VEGF agents were instituted in four cases, in an as-required protocol. 1 patient received systemic steroid.Conclusions: The development of MEWDS-like phenotypes in association with CNVM can occur in eyes with either inflammatory or non-inflammatory CNVM, and in those who were or were not treated with anti-VEGF therapy. The association suggests an inflammatory event, which causes RPE changes and probably induces the development of the CNV.
Entities:
Keywords:
Multifocal eveanescent white dot syndrome; autoflurescence; choroidal neovascularization