Literature DB >> 3412473

Vaccinia virus encodes a secretory polypeptide structurally related to complement control proteins.

G J Kotwal1, B Moss.   

Abstract

Several polypeptides are secreted into the medium of cells infected with vaccinia virus, a cytoplasmic DNA virus belonging to the poxvirus family. One of these, a polypeptide of relative molecular mass 19,000 is structurally related to epidermal growth factor and binds to epidermal growth factor receptor stimulating proliferation of uninfected cells in vitro and in vivo. Here, we show that a second, and much more abundant secretory polypeptide, is also encoded by vaccinia virus and is structurally related to the superfamily of complement control proteins. Members of this family can block complement-mediated induction of the inflammatory response, and engulfment, killing and lysis of bacteria and viruses.

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Year:  1988        PMID： 3412473     DOI： 10.1038/335176a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  101 in total

1.  Conserved surface-exposed K/R-X-K/R motifs and net positive charge on poxvirus complement control proteins serve as putative heparin binding sites and contribute to inhibition of molecular interactions with human endothelial cells: a novel mechanism for evasion of host defense.

Authors:  S A Smith; N P Mullin; J Parkinson; S N Shchelkunov; A V Totmenin; V N Loparev; R Srisatjaluk; D N Reynolds; K L Keeling; D E Justus; P N Barlow; G J Kotwal
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

2.  Species-specific differences in the organization of the complement-binding protein of orthopoxviruses.

Authors:  S N Shchelkunov; E A Uvarova; A V Totmenin; P F Safronov; L S Sandakhchiev
Journal:  Dokl Biochem Biophys       Date:  2001 Jul-Aug       Impact factor: 0.788

3.  Microbial subversion of the immune response.

Authors:  P J Lachmann
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-19       Impact factor: 11.205

Review 4.  Poxvirus immunomodulatory strategies: current perspectives.

Authors:  J B Johnston; Grant McFadden
Journal:  J Virol       Date:  2003-06       Impact factor: 5.103

5.  New member of the multigene family of complement control proteins in herpesvirus saimiri.

Authors:  J C Albrecht; B Fleckenstein
Journal:  J Virol       Date:  1992-06       Impact factor: 5.103

6.  Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention.

Authors:  Anton V Cheltsov; Mika Aoyagi; Alexander Aleshin; Eric Chi-Wang Yu; Taylor Gilliland; Dayong Zhai; Andrey A Bobkov; John C Reed; Robert C Liddington; Ruben Abagyan
Journal:  J Med Chem       Date:  2010-05-27       Impact factor: 7.446

7.  The agnoprotein of polyomavirus JC is released by infected cells: evidence for its cellular uptake by uninfected neighboring cells.

Authors:  Onder Otlu; Francesca Isabella De Simone; Yolanda-Lopez Otalora; Kamel Khalili; Ilker Kudret Sariyer
Journal:  Virology       Date:  2014-08-23       Impact factor: 3.616

8.  Role of genes that modulate host immune responses in the immunogenicity and pathogenicity of vaccinia virus.

Authors:  Shawn S Jackson; Petr Ilyinskii; Valérie Philippon; Linda Gritz; Alicia Gómez Yafal; Kimberly Zinnack; Kristin R Beaudry; Kelledy H Manson; Michelle A Lifton; Marcelo J Kuroda; Norman L Letvin; Gail P Mazzara; Dennis L Panicali
Journal:  J Virol       Date:  2005-05       Impact factor: 5.103

9.  Identification of complement regulatory domains in vaccinia virus complement control protein.

Authors:  Jayati Mullick; John Bernet; Yogesh Panse; Sharanabasava Hallihosur; Akhilesh K Singh; Arvind Sahu
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

10.  Venom and viral expression products of the endoparasitic wasp Campoletis sonorensis share epitopes and related sequences.

Authors:  B A Webb; M D Summers
Journal:  Proc Natl Acad Sci U S A       Date:  1990-07       Impact factor: 11.205
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