Literature DB >> 34123951

Blood Culture-negative Endocarditis Caused by Tropheryma whipplei: Whipple's endocarditis.

Silke Knol1, Rogier L Nijhuis1, Felix Geeraedts2, Gerard Cm Linssen1.   

Abstract

CASE DESCRIPTION: A 67-year-old man was admitted with progressive heart failure due to blood culture-negative endocarditis of the aortic valve. Urgent aortic valve replacement was needed. Polymerase chain reaction (PCR) testing of samples of the explanted aortic valve revealed Tropheryma whipplei. The patient received ceftriaxone, followed by long-term co-trimoxazole. Recent arthralgia may have been a diagnostic clue.
CONCLUSION: Whipple's endocarditis should be considered in patients with arthralgia and blood culture-negative endocarditis (BCNIE). LEARNING POINTS: Whipple's endocarditis should be considered in patients with symptoms of arthralgia and blood culture-negative endocarditis (BCNIE).Serum polymerase chain reaction is the main diagnostic test.Both physician awareness and multidisciplinary management by regional endocarditis teams are recommended strategies to provide optimal patient care. © EFIM 2021.

Entities:  

Keywords:  Tropheryma whipplei; Whipple’s endocarditis; blood culture-negative endocarditis

Year:  2021        PMID： 34123951      PMCID： PMC8191359          DOI： 10.12890/2021_002596

Source DB:  PubMed          Journal:  Eur J Case Rep Intern Med        ISSN： 2284-2594


  5 in total

1.  Intravenous ceftriaxone, followed by 12 or three months of oral treatment with trimethoprim-sulfamethoxazole in Whipple's disease.

Authors:  Gerhard E Feurle; Verena Moos; Hendrik Bläker; Christoph Loddenkemper; Annette Moter; Andrea Stroux; Thomas Marth; Thomas Schneider
Journal:  J Infect       Date:  2013-01-03       Impact factor: 6.072

Review 2.  Clinical Manifestations, Treatment, and Diagnosis of Tropheryma whipplei Infections.

Authors:  Ruben A V Dolmans; C H Edwin Boel; Miangela M Lacle; Johannes G Kusters
Journal:  Clin Microbiol Rev       Date:  2017-04       Impact factor: 26.132

3.  2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM).

Authors:  Gilbert Habib; Patrizio Lancellotti; Manuel J Antunes; Maria Grazia Bongiorni; Jean-Paul Casalta; Francesco Del Zotti; Raluca Dulgheru; Gebrine El Khoury; Paola Anna Erba; Bernard Iung; Jose M Miro; Barbara J Mulder; Edyta Plonska-Gosciniak; Susanna Price; Jolien Roos-Hesselink; Ulrika Snygg-Martin; Franck Thuny; Pilar Tornos Mas; Isidre Vilacosta; Jose Luis Zamorano
Journal:  Eur Heart J       Date:  2015-08-29       Impact factor: 29.983

4.  Whipple's endocarditis: a case report of a blood culture-negative endocarditis.

Authors:  Miriam A Scheurwater; Cees M Verduin; Jan-Melle van Dantzig
Journal:  Eur Heart J Case Rep       Date:  2019-12-17

5.  Arthralgia and blood culture-negative endocarditis in middle Age Men suggest tropheryma whipplei infection: report of two cases and review of the literature.

Authors:  Anthony Alozie; Annette Zimpfer; Kerstin Köller; Bernd Westphal; Annette Obliers; Andreas Erbersdobler; Gustav Steinhoff; Andreas Podbielski
Journal:  BMC Infect Dis       Date:  2015-08-18       Impact factor: 3.090
  5 in total

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