Literature DB >> 34123939

Diffuse Calcinosis from Total Thyroidectomy and Secondary Hypocalcaemia.

Filipa Leal1, Luís Nogueira1, Teresa Martins Mendes1, Ana Silva Rocha1, Dinis Sarmento1, Francisco Pombo1, Bárbara Silva1.   

Abstract

Hypoparathyroidism is a rare endocrine disorder and its main cause is cervical surgery such as thyroidectomy. The incidence of hypoparathyroidism after total thyroidectomy varies, and is reported to be between 0.3 and 6.3%. In terms of brain imaging, hypoparathyroidism can cause calcification mainly of the basal ganglia, with other areas rarely affected. Concerning extracerebral calcification, few studies have investigated the prevalence of visceral calcifications. We describe a case of a woman with secondary hypocalcaemia who presented with a transient ischaemic attack (TIA) and the investigation revealed an extensive calcinosis of the brain and the vascular structures responsible for the event. LEARNING POINTS: Iatrogenic hypoparathyroidism with hypocalcaemia is an important complication of total thyroidectomy. Hypocalcaemia manifestations can vary from asymptomatic to life-threatening conditions.Hypoparathyroidism (with hypocalcaemia) can cause cerebral calcification mainly of basal ganglia, with other areas of the brain rarely affected.Extracerebral calcifications are under-studied. © EFIM 2021.

Entities:  

Keywords:  Hypoparathyroidism; brain calcinosis syndrome; cerebral calcifications

Year:  2021        PMID: 34123939      PMCID: PMC8191350          DOI: 10.12890/2021_002489

Source DB:  PubMed          Journal:  Eur J Case Rep Intern Med        ISSN: 2284-2594


  8 in total

Review 1.  Diagnosis and management of hypocalcaemia.

Authors:  Mark S Cooper; Neil J L Gittoes
Journal:  BMJ       Date:  2008-06-07

2.  Looking beyond the obvious: cerebral calcification.

Authors:  Simon W Lines; Hawraman Ramadan
Journal:  Pract Neurol       Date:  2013-07-11

3.  Long-term follow-up of patients with hypoparathyroidism.

Authors:  Deborah M Mitchell; Susan Regan; Michael R Cooley; Kelly B Lauter; Michael C Vrla; Carolyn B Becker; Sherri-Ann M Burnett-Bowie; Michael Mannstadt
Journal:  J Clin Endocrinol Metab       Date:  2012-10-05       Impact factor: 5.958

Review 4.  Review of Hypoparathyroidism.

Authors:  Ejigayehu G Abate; Bart L Clarke
Journal:  Front Endocrinol (Lausanne)       Date:  2017-01-16       Impact factor: 5.555

Review 5.  Basal ganglia calcifications (Fahr's syndrome): related conditions and clinical features.

Authors:  Giulia Donzuso; Giovanni Mostile; Alessandra Nicoletti; Mario Zappia
Journal:  Neurol Sci       Date:  2019-07-02       Impact factor: 3.307

6.  Prevalence of basal ganglia and carotid artery calcifications in patients with permanent hypoparathyroidism after total thyroidectomy.

Authors:  Leyre Lorente-Poch; Sílvia Rifà-Terricabras; Juan José Sancho; Danilo Torselli-Valladares; Sofia González-Ortiz; Antonio Sitges-Serra
Journal:  Endocr Connect       Date:  2020-10       Impact factor: 3.335

7.  Extensive bilateral intracranial calcifications: a case of iatrogenic hypoparathyroidism.

Authors:  Vaso Zisimopoulou; Anna Siatouni; Grigorios Tsoukalos; Antonios Tavernarakis; Stylianos Gatzonis
Journal:  Case Rep Med       Date:  2013-02-24

8.  A rare cause of seizures, parkinsonian, and cerebellar signs: brain calcinosis secondary to thyroidectomy.

Authors:  Rakesh Agarwal; Durjoy Lahiri; Amrita Biswas; Jotideb Mukhopadhyay; Pranab Maity; Manoj Kumar Roy
Journal:  N Am J Med Sci       Date:  2014-10
  8 in total

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