Literature DB >> 34122151

Corrigendum: Targeting Endolysosomal Two-Pore Channels to Treat Cardiovascular Disorders in the Novel COronaVIrus Disease 2019.

Francesco Moccia1, Sharon Negri1, Pawan Faris1, Angelica Perna2, Antonio De Luca3, Teresa Soda4, Roberto Berra-Romani5, Germano Guerra2.   

Abstract

[This corrects the article DOI: 10.3389/fphys.2021.629119.].
Copyright © 2021 Moccia, Negri, Faris, Perna, De Luca, Soda, Berra-Romani and Guerra.

Entities:  

Keywords:  COVID-19; NAADP; PI(3,5)P2; SARS-CoV-2; cardiovascular system; endolysosomal Ca2+ signaling; two-pore channels

Year:  2021        PMID: 34122151      PMCID: PMC8195275          DOI: 10.3389/fphys.2021.690189

Source DB:  PubMed          Journal:  Front Physiol        ISSN: 1664-042X            Impact factor:   4.566


An author name was incorrectly spelled as Roberto-Berra Romani. The correct spelling is Roberto Berra-Romani. In the original article Penny et al. (2019) was not cited in the article. The citation has now been inserted in “4. TPCs mediate entry and trafficking of viruses in host cells” and should read: A recent screening campaign confirmed that TPC2 activation regulates EBOV entry in host cells. Measurement of PI(3,5)P2-evoked lysosomal currents, NAADP-induced Ca2+ release and single-channel activity, revealed that FDA-approved dopamine antagonists, such as pimozide and fluphenazine, and selective estrogen receptor modulators, such as clomiphene and raloxifene, were also able to target TPC2 by plugging the channel pore (Penny et al., 2019). Furthermore, these novel inhibitors of TPC2 effectively reduced EBOV infection in vitro (Penny et al., 2019). In the original article, there was an error. The assertion “Subsequently, the same group demonstrated that TPC2 also regulates MERS-CoV infectivity” is not correct as these findings were obtained by two different groups. A correction has been made to “4. TPCs mediate entry and trafficking of viruses in host cells”: Subsequently, TPC2 was found to also regulate MERS-CoV infectivity. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
  1 in total

1.  Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers.

Authors:  Christopher J Penny; Kristin Vassileva; Archana Jha; Yu Yuan; Xavier Chee; Elizabeth Yates; Michela Mazzon; Bethan S Kilpatrick; Shmuel Muallem; Mark Marsh; Taufiq Rahman; Sandip Patel
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2018-11-05       Impact factor: 4.739

  1 in total

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