Daniela Parrino1, Andrea Frosolini1, Chiara Gallo1, Romolo Daniele De Siati2, Giacomo Spinato3, Cosimo de Filippis1. 1. Department of Neuroscience DNS, Audiology and Phoniatrics Unit, University of Padova, Treviso, Italy. 2. Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium. 3. Department of Neurosciences DNS, Section of Otolaryngology and Regional Centre for Head and Neck Cancer, University of Padova, Treviso, Italy.
Abstract
OBJECTIVE: To ensure the safety and quality of vaccines, especially the newest RNA-vaccines against COVID-19, is one of the World Health Organization's current highest priorities. DESIGN: Case description. STUDY SAMPLE: We report three cases of sudden unilateral tinnitus following BNT162b2 mRNA-vaccine injection, which rapidly resolved in 2 out of 3 cases. RESULTS: The mechanism responsible for its development remains unclear. A hypersensitivity reaction with an abnormal autoimmune response or a vasculitic event may be implicated. CONCLUSIONS: Large-scale and well-designed studies are needed to improve surveillance of the COVID-19 vaccine and better define possible adverse reactions involving the cochleo-vestibular system and/or immunisation anxiety-related reactions.
OBJECTIVE: To ensure the safety and quality of vaccines, especially the newest RNA-vaccines against COVID-19, is one of the World Health Organization's current highest priorities. DESIGN: Case description. STUDY SAMPLE: We report three cases of sudden unilateral tinnitus following BNT162b2 mRNA-vaccine injection, which rapidly resolved in 2 out of 3 cases. RESULTS: The mechanism responsible for its development remains unclear. A hypersensitivity reaction with an abnormal autoimmune response or a vasculitic event may be implicated. CONCLUSIONS: Large-scale and well-designed studies are needed to improve surveillance of the COVID-19 vaccine and better define possible adverse reactions involving the cochleo-vestibular system and/or immunisation anxiety-related reactions.
Entities:
Keywords:
BNT162b2; COVID-19; side effects; tinnitus; vaccine
Authors: Davide Pisani; Federico Maria Gioacchini; Pasquale Viola; Alfonso Scarpa; Alessia Astorina; Massimo Re; Gianmarco Marcianò; Francesco Manti; Roberta Anzivino; Giuseppe Chiarella Journal: Audiol Res Date: 2022-04-21
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