Yuling Tong1, Hongguang Wang2, Yi Zhao1, Xueqiang He3, Hongwei Xu4, Hong Li5, Ping Shuai6, Lirong Gong6, Hongbo Wu7, Hongzhi Xu8, Yinhu Luo9, Dong Wang10, Shizhu Liu2, Zhenya Song11. 1. Department of General Practice/Health Management Center, The Second Affiliated Hospital of Zhejiang University, School of Medicine, No. 88 Jiefang Road, Hangzhou, China. 2. Department of Gastroenterology, Jilin City People's Hospital, Jilin, China. 3. Department of Gastroenterology, No. 924 Hospital of the People's Liberation Army of China, Guilin, China. 4. Department of Gastroenterology, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, China. 5. Department of Health Medicine, Chinese PLA General Hospital, Beijing, China. 6. Health Management Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. 7. Department of Gastroenterology, The First Hospital Affiliated to AMU (Southwest Hospital), Chongqing, China. 8. Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, China. 9. Department of Gastroenterology, Jingzhou Hospital of Traditional Chinese Medicine, Jingzhou, China. 10. Department of Gastroenterology, Shanghai Changhai Hospital, Shanghai, China. 11. Department of General Practice/Health Management Center, The Second Affiliated Hospital of Zhejiang University, School of Medicine, No. 88 Jiefang Road, Hangzhou, China. songzhenya@zju.edu.cn.
Abstract
BACKGROUND: The aim of this study is to investigate the difference of serum pepsinogen (PG) baseline levels in different regions of China and its influencing factors. METHODS: From October 2016 to October 2018, asymptomatic health checkup people who underwent nasal endoscopy in nine health management centers in different regions of China were collected. Lifestyle questionnaires were conducted, and serum PG and gastroscopy were performed. The differences in PG levels in baseline population (OLGA-0 grade) were studied according to geographical subregions of China. SPSS software was used for statistical analysis. RESULTS: 1922 patients were included in the final analysis. Compared with the non-atrophy (OLGA-0) group, PGR levels in atrophy group (OLGA-I to IV) were significantly decreased with the atrophy degree (p < 0.05). A total of 1590 baseline people (OLGA-0) were included in the study, including 254 from South China, 574 from East China, 210 from Southwest China, 332 from Northeast China, and 220 from Central/Northern China. There were significant differences in baseline PGI levels among the five regions (p < 0.05). The PGII levels were also different among the five regions, except for Central/Northern versus Southern China. PGR (PGI/PGII ratio) levels in Southern China were higher than other four regions. Further studies were conducted on the related factors that might affect the baseline PG level, which was affected by nationality, dietary habits, smoking, Helicobacter pylori infection and other related factors. CONCLUSION: Influenced by many factors, the baseline PG levels are different in different regions of China. In the follow-up studies of PG cut-off value, different PG cut-off value based on region may be more effective in the screening of gastric cancer and precancerous lesions in China.
BACKGROUND: The aim of this study is to investigate the difference of serum pepsinogen (PG) baseline levels in different regions of China and its influencing factors. METHODS: From October 2016 to October 2018, asymptomatic health checkup people who underwent nasal endoscopy in nine health management centers in different regions of China were collected. Lifestyle questionnaires were conducted, and serum PG and gastroscopy were performed. The differences in PG levels in baseline population (OLGA-0 grade) were studied according to geographical subregions of China. SPSS software was used for statistical analysis. RESULTS: 1922 patients were included in the final analysis. Compared with the non-atrophy (OLGA-0) group, PGR levels in atrophy group (OLGA-I to IV) were significantly decreased with the atrophy degree (p < 0.05). A total of 1590 baseline people (OLGA-0) were included in the study, including 254 from South China, 574 from East China, 210 from Southwest China, 332 from Northeast China, and 220 from Central/Northern China. There were significant differences in baseline PGI levels among the five regions (p < 0.05). The PGII levels were also different among the five regions, except for Central/Northern versus Southern China. PGR (PGI/PGII ratio) levels in Southern China were higher than other four regions. Further studies were conducted on the related factors that might affect the baseline PG level, which was affected by nationality, dietary habits, smoking, Helicobacter pyloriinfection and other related factors. CONCLUSION: Influenced by many factors, the baseline PG levels are different in different regions of China. In the follow-up studies of PG cut-off value, different PG cut-off value based on region may be more effective in the screening of gastric cancer and precancerous lesions in China.
Entities:
Keywords:
Baseline survey; Different regions of China; Influencing factors; Serum pepsinogen
Authors: M Rugge; M de Boni; G Pennelli; M de Bona; L Giacomelli; M Fassan; D Basso; M Plebani; D Y Graham Journal: Aliment Pharmacol Ther Date: 2010-02-23 Impact factor: 8.171