Daoran Dong1, Yuan Zong2, Zhuo Li2, Yan Wang2, Chengqiao Jing2. 1. Department of ICU, Shaanxi Provincial People's Hospital, Xi'an, China. Electronic address: sxsrmyyicu11@outlook.com. 2. Department of ICU, Shaanxi Provincial People's Hospital, Xi'an, China.
Abstract
BACKGROUND: The impact of right ventricular dysfunction(RVD) on the prognosis of acute respiratory distress syndrome(ARDS) patients is controversial. OBJECTIVES: The objectives of this systematic review and meta-analysis was to investigate whether RVD or pulmonary vascular dysfunction are associated with increased mortality in patients with ARDS. METHODS: We searched Pubmed, Embase, Cochrane Library, Wanfang Data, CNKI, and the WHO Clinical Trial Registry for studies of RVD or pulmonary vascular dysfunction in patients with ARDS. RESULTS: The presence of RVD or pulmonary vascular dysfunction in patients with ARDS was associated with an increase in mortality (OR = 1.68, 95% CI = 1.21-2.32, P = 0.069, I2 = 40.8%). Subgroup analyses obtained similar results. Funnel plots and the Egger's test indicated no publication bias, and sensitivity analyses determined that the results were stable. CONCLUSION: The prognosis of patients with ARDS and RVD or pulmonary vascular dysfunction is worse than that of ARDS patients without RVD or pulmonary vascular dysfunction.
BACKGROUND: The impact of right ventricular dysfunction(RVD) on the prognosis of acute respiratory distress syndrome(ARDS) patients is controversial. OBJECTIVES: The objectives of this systematic review and meta-analysis was to investigate whether RVD or pulmonary vascular dysfunction are associated with increased mortality in patients with ARDS. METHODS: We searched Pubmed, Embase, Cochrane Library, Wanfang Data, CNKI, and the WHO Clinical Trial Registry for studies of RVD or pulmonary vascular dysfunction in patients with ARDS. RESULTS: The presence of RVD or pulmonary vascular dysfunction in patients with ARDS was associated with an increase in mortality (OR = 1.68, 95% CI = 1.21-2.32, P = 0.069, I2 = 40.8%). Subgroup analyses obtained similar results. Funnel plots and the Egger's test indicated no publication bias, and sensitivity analyses determined that the results were stable. CONCLUSION: The prognosis of patients with ARDS and RVD or pulmonary vascular dysfunction is worse than that of ARDSpatients without RVD or pulmonary vascular dysfunction.
Authors: Bruno Evrard; Marine Goudelin; Bruno Giraudeau; Bruno François; Philippe Vignon Journal: Intensive Care Med Date: 2022-05-12 Impact factor: 41.787