Xuena Yang1, Jing Ye1, Bolun Cheng1, Shiqiang Cheng1, Li Liu1, Peilin Meng1, Chujun Liang1, Yao Yao1, Yan Wen1, Zhen Zhang1, Chun'e Li1, Huijie Zhang1, Yujing Chen1, Jingxi Zhang1, Chuyu Pan1, Yumeng Jia2, Feng Zhang3. 1. Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China. 2. Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China. Electronic address: jiayumemg@mail.xjtu.edu.cn. 3. Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China. Electronic address: fzhxjtu@mail.xjtu.edu.cn.
Abstract
OBJECTIVE: This study was aimed to evaluate the associations of adult heel bone mineral density (BMD) with birth weight and growth parameters at the age of ten years. METHODS: The analysis data (97178-178,494 subjects) was derived from the UK Biobank cohort. Birth weight, comparative body size and height size at the age of ten years were determined by self-report. The heel BMD was estimated by the Quantitative Ultrasound Index through the calcaneus. Linear regression analysis was applied to test the associations of adult heel BMD with birth weight and growth parameters at the age of ten years, respectively. Age, sex, body mass index and 10 principle components (PC) of population structure were used as covariates in the regression analysis of total samples. In sex-specific analysis, age, body mass index and 10 PC were used as covariates. RESULTS: We observed significant associations of heel BMD with birth weight (b = -0.020, P = 1.974 × 10-13), comparative body size (b = 0.020, P = 2.539 × 10-6) and comparative height size (b = -0.020, P = 5.892 × 10-11) at the age of ten years in total samples. In females, birth weight (b = -0.040, P = 2.870 × 10-24) and comparative height size (b = -0.040, P = 2.034 × 10-20) were statistically associated with adult heel BMD. In males, comparative body size appeared to be associated with adult heel BMD (b = 0.030, P = 1.590 × 10-7). CONCLUSION: Our study results support the predictive effects of birth weight and growth parameters at the age of ten years on adult heel BMD. We also observed sex-specific association between adult heel BMD and growth parameters at the age of ten years.
OBJECTIVE: This study was aimed to evaluate the associations of adult heel bone mineral density (BMD) with birth weight and growth parameters at the age of ten years. METHODS: The analysis data (97178-178,494 subjects) was derived from the UK Biobank cohort. Birth weight, comparative body size and height size at the age of ten years were determined by self-report. The heel BMD was estimated by the Quantitative Ultrasound Index through the calcaneus. Linear regression analysis was applied to test the associations of adult heel BMD with birth weight and growth parameters at the age of ten years, respectively. Age, sex, body mass index and 10 principle components (PC) of population structure were used as covariates in the regression analysis of total samples. In sex-specific analysis, age, body mass index and 10 PC were used as covariates. RESULTS: We observed significant associations of heel BMD with birth weight (b = -0.020, P = 1.974 × 10-13), comparative body size (b = 0.020, P = 2.539 × 10-6) and comparative height size (b = -0.020, P = 5.892 × 10-11) at the age of ten years in total samples. In females, birth weight (b = -0.040, P = 2.870 × 10-24) and comparative height size (b = -0.040, P = 2.034 × 10-20) were statistically associated with adult heel BMD. In males, comparative body size appeared to be associated with adult heel BMD (b = 0.030, P = 1.590 × 10-7). CONCLUSION: Our study results support the predictive effects of birth weight and growth parameters at the age of ten years on adult heel BMD. We also observed sex-specific association between adult heel BMD and growth parameters at the age of ten years.
Authors: Mona M Elghareeb; Gehad E Elshopakey; Tarek A Elkhooly; Basma Salama; Alaa Samy; Fuller W Bazer; Mohammed A Elmetwally; Mikhlid H Almutairi; Lotfi Aleya; Mohamed M Abdel-Daim; Shaymaa Rezk Journal: Front Physiol Date: 2022-09-19 Impact factor: 4.755