Alexis R Demonbreun1,2, Amelia Sancilio3, Matt E Velez1,4, Daniel T Ryan5, Lorenzo Pesce1,2, Rana Saber5, Lauren A Vaught1,4, Nina L Reiser1,4, Ryan R Hsieh1,4, Richard T D'Aquila6, Brian Mustanski5, Thomas W McDade3, Elizabeth M McNally1,4,7. 1. Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 2. Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 3. Department of Anthropology and Institute for Policy Research, Northwestern University, Evanston, IL, USA. 4. Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 5. Institute for Sexual and Gender Minority Health and Wellbeing and Department of Medical Social Sciences, Northwestern University, Chicago, IL, USA. 6. Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 7. Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.
Abstract
QUESTION: Is antibody response to COVID-19 mRNA vaccination similar in women and men? FINDINGS: In a community cohort without prior COVID-19 infection, the first vaccine dose produced higher IgG levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0µg/ml; 51.6% vs 3.3µg/ml; 36.4%). After two doses, IgG levels remained significantly higher for women (30.4µg/ml) compared to men (20.6µg/ml), while percent inhibition was similar (98.4% vs 97.7%). MEANING: Sex-specific antibody response to mRNA vaccination informs future efforts to understand vaccine protection and side effects.
QUESTION: Is antibody response to COVID-19 mRNA vaccination similar in women and men? FINDINGS: In a community cohort without prior COVID-19infection, the first vaccine dose produced higher IgG levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0µg/ml; 51.6% vs 3.3µg/ml; 36.4%). After two doses, IgG levels remained significantly higher for women (30.4µg/ml) compared to men (20.6µg/ml), while percent inhibition was similar (98.4% vs 97.7%). MEANING: Sex-specific antibody response to mRNA vaccination informs future efforts to understand vaccine protection and side effects.
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