Literature DB >> 3411455

Differential metabolism of the enantiomers of primaquine.

J K Baker1, J D McChesney.   

Abstract

When racemic primaquine was administered to rats, the majority of the residual primaquine excreted in urine was found to be the (+)-isomer. Using a liver microsome preparation, there was no selectivity in the metabolism of the (+)- and (-)-isomers; however, a liver fraction containing mitochondria and microsomes did show selectivity. In the latter preparation, there was a marked preference for the conversion of (-)-primaquine to (-)-carboxy-primaquine.

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Year:  1988        PMID： 3411455     DOI： 10.1002/jps.2600770503

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  6 in total

1.  Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta).

Authors:  David Saunders; Pattaraporn Vanachayangkul; Rawiwan Imerbsin; Phisit Khemawoot; Raveewan Siripokasupkul; Babu L Tekwani; Aruna Sampath; N P Dhammika Nanayakkara; Colin Ohrt; Charlotte Lanteri; Montip Gettyacamin; Paktiya Teja-Isavadharm; Larry Walker
Journal:  Antimicrob Agents Chemother       Date:  2014-09-29       Impact factor: 5.191

2.  Simultaneous and enantiospecific quantification of primaquine and carboxyprimaquine in human plasma using liquid chromatography-tandem mass spectrometry.

Authors:  Warunee Hanpithakpong; Nicholas P J Day; Nicholas J White; Joel Tarning
Journal:  Malar J       Date:  2022-06-03       Impact factor: 3.469

3.  Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate.

Authors:  N P Dhammika Nanayakkara; Arba L Ager; Marilyn S Bartlett; Vanessa Yardley; Simon L Croft; Ikhlas A Khan; James D McChesney; Larry A Walker
Journal:  Antimicrob Agents Chemother       Date:  2008-03-31       Impact factor: 5.191

4.  Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers.

Authors:  N P Dhammika Nanayakkara; Babu L Tekwani; H M T Bandara Herath; Rajnish Sahu; Montip Gettayacamin; Anchalee Tungtaeng; Yvonne van Gessel; Paul Baresel; Kristina S Wickham; Marilyn S Bartlett; Frank R Fronczek; Victor Melendez; Colin Ohrt; Gregory A Reichard; James D McChesney; Rosemary Rochford; Larry A Walker
Journal:  Antimicrob Agents Chemother       Date:  2014-06-09       Impact factor: 5.191

5.  Comparative pharmacokinetics and tissue distribution of primaquine enantiomers in mice.

Authors:  Pius S Fasinu; Narayan D Chaurasiya; N P Dhammika Nanayakkara; Yan-Hong Wang; H M T Bandara Herath; Bharathi Avula; James D McChesney; David Jollow; Larry A Walker; Babu L Tekwani
Journal:  Malar J       Date:  2022-02-05       Impact factor: 2.979

6.  Enantiospecific pharmacokinetics and drug-drug interactions of primaquine and blood-stage antimalarial drugs.

Authors:  Kalayanee Chairat; Podjanee Jittamala; Borimas Hanboonkunupakarn; Sasithon Pukrittayakamee; Warunee Hanpithakpong; Daniel Blessborn; Nicholas J White; Nicholas P J Day; Joel Tarning
Journal:  J Antimicrob Chemother       Date:  2018-11-01       Impact factor: 5.790
  6 in total

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