Alaina M Bever1,2, Aedin Cassidy3, Eric B Rimm2,4, Meir J Stampfer1,2,4, David J Cote1,2. 1. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. 2. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 3. Institute for Global Food Security, Queen's University Belfast, Belfast, United Kingdom. 4. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Abstract
BACKGROUND: Flavonoids are a diverse group of plant constituents with demonstrated neuroprotective and anti-tumor effects. Flavonoid intake may decrease the risk of glioma, but the possibility of an association has not yet been investigated in humans. OBJECTIVES: We evaluated the association between dietary flavonoid consumption and the risk of glioma. METHODS: We followed participants in the female Nurses' Health Study (1984-2014; n = 81,688) and Nurses' Health Study II (1991-2017; n = 95,228) and the male Health Professionals Follow-Up Study (1986-2014; n = 49,885). We used multivariable-adjusted Cox proportional hazards regression models to evaluate the associations between average long-term (up to 30 years) or recent (up to 12 years) dietary flavonoid intake (total flavonoids and each of 6 subclasses) and risks of incident glioma. Flavonoid intake was derived from validated quadrennial FFQs. Incident glioma was self-reported and confirmed by a medical record review or was determined by a medical record review after death. RESULTS: We documented 536 incident cases of glioma across 5,936,386 person-years of follow-up. Long-term total flavonoid, flavan-3-ol, and polymeric flavonoid (polymer) intakes were associated with decreased glioma risks in pooled analyses comparing the highest to lowest quintiles of consumption [HR, 0.79 (95% CI, 0.59-1.05; P-trend = 0.04) for total flavonoids; 0.76 (95% CI, 0.57-1.01; P-trend = 0.04) for flavan-3-ols; and 0.82 (95% CI, 0.61-1.09; P-trend = 0.05) for polymers]. Associations with recent intake were weaker. There were no associations with other flavonoid subclasses. After additional adjustment for tea consumption, there were no associations between flavan-3-ol or polymer consumption and glioma. CONCLUSIONS: Increased dietary intakes of flavan-3-ol and polymeric flavonoids, especially those predominant in tea, were associated with decreased glioma risks in a prospective cohort of men and women.
BACKGROUND: Flavonoids are a diverse group of plant constituents with demonstrated neuroprotective and anti-tumor effects. Flavonoid intake may decrease the risk of glioma, but the possibility of an association has not yet been investigated in humans. OBJECTIVES: We evaluated the association between dietary flavonoid consumption and the risk of glioma. METHODS: We followed participants in the female Nurses' Health Study (1984-2014; n = 81,688) and Nurses' Health Study II (1991-2017; n = 95,228) and the male Health Professionals Follow-Up Study (1986-2014; n = 49,885). We used multivariable-adjusted Cox proportional hazards regression models to evaluate the associations between average long-term (up to 30 years) or recent (up to 12 years) dietary flavonoid intake (total flavonoids and each of 6 subclasses) and risks of incident glioma. Flavonoid intake was derived from validated quadrennial FFQs. Incident glioma was self-reported and confirmed by a medical record review or was determined by a medical record review after death. RESULTS: We documented 536 incident cases of glioma across 5,936,386 person-years of follow-up. Long-term total flavonoid, flavan-3-ol, and polymeric flavonoid (polymer) intakes were associated with decreased glioma risks in pooled analyses comparing the highest to lowest quintiles of consumption [HR, 0.79 (95% CI, 0.59-1.05; P-trend = 0.04) for total flavonoids; 0.76 (95% CI, 0.57-1.01; P-trend = 0.04) for flavan-3-ols; and 0.82 (95% CI, 0.61-1.09; P-trend = 0.05) for polymers]. Associations with recent intake were weaker. There were no associations with other flavonoid subclasses. After additional adjustment for tea consumption, there were no associations between flavan-3-ol or polymer consumption and glioma. CONCLUSIONS: Increased dietary intakes of flavan-3-ol and polymeric flavonoids, especially those predominant in tea, were associated with decreased glioma risks in a prospective cohort of men and women.
Authors: Elizandra Braganhol; Lauren L Zamin; Andrés Delgado Canedo; Fabiana Horn; Alessandra S K Tamajusuku; Márcia R Wink; Christianne Salbego; Ana M O Battastini Journal: Anticancer Drugs Date: 2006-07 Impact factor: 2.248
Authors: E B Rimm; E L Giovannucci; W C Willett; G A Colditz; A Ascherio; B Rosner; M J Stampfer Journal: Lancet Date: 1991-08-24 Impact factor: 79.321
Authors: Thomas C Chen; Weijun Wang; Encouse B Golden; Simmy Thomas; Walavan Sivakumar; Florence M Hofman; Stan G Louie; Axel H Schönthal Journal: Cancer Lett Date: 2011-01-22 Impact factor: 8.679
Authors: David J Cote; Alaina M Bever; Kathryn M Wilson; Timothy R Smith; Stephanie A Smith-Warner; Meir J Stampfer Journal: Int J Cancer Date: 2019-07-26 Impact factor: 7.396
Authors: W C Willett; L Sampson; M J Stampfer; B Rosner; C Bain; J Witschi; C H Hennekens; F E Speizer Journal: Am J Epidemiol Date: 1985-07 Impact factor: 4.897
Authors: Crystal N Holick; Scott G Smith; Edward Giovannucci; Dominique S Michaud Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-01 Impact factor: 4.254
Authors: Yiyang Yue; Joshua Petimar; Walter C Willett; Stephanie A Smith-Warner; Changzheng Yuan; Sinara Rosato; Laura Sampson; Bernard Rosner; Aedin Cassidy; Eric B Rimm; Kerry L Ivey Journal: Public Health Nutr Date: 2020-07-23 Impact factor: 4.022
Authors: David J Cote; Alaina M Bever; Yu-Han Chiu; Helena Sandoval-Insausti; Stephanie A Smith-Warner; Jorge E Chavarro; Meir J Stampfer Journal: Am J Epidemiol Date: 2022-03-24 Impact factor: 5.363
Authors: Ravena Pereira do Nascimento; Balbino Lino Dos Santos; Jéssika Alves Oliveira Amparo; Janaina Ribeiro Pereira Soares; Karina Costa da Silva; Monique Reis Santana; Áurea Maria Alves Nunes Almeida; Victor Diógenes Amaral da Silva; Maria de Fátima Dias Costa; Henning Ulrich; Vivaldo Moura-Neto; Giselle Pinto de Faria Lopes; Silvia Lima Costa Journal: Pharmaceutics Date: 2022-01-04 Impact factor: 6.321