Surgical Outcomes of Rhegmatogenous Retinal Detachment with Different Peripheral Vitreous-Shaving Procedures.

PURPOSE: To compare the surgical outcomes of vitreous surgery for rhegmatogenous retinal detachment (RRD) after two different peripheral vitreous-shaving techniques are performed.
METHODS: We reviewed 269 eyes with RRD that were treated with a 25-gauge vitrectomy by a single surgeon between June 2015 and May 2020. The exclusion criteria for the proposed air tamponade selection were as follows: more than two weeks since RRD onset, giant retinal tears, a history of complications following cataract surgery, high myopia, and proliferative vitreoretinopathy classified as grade C or higher. We examined the differences in the therapeutic effect between shaving under slit lamp microscope illumination (group A) and shaving under a wide-angle viewing system (group B).
RESULTS: A total of 269 eyes were included in this study, with 146 eyes in group A and 123 eyes in group B. The primary anatomical success rates did not differ between group A (97.3%; 142/146 eyes) and group B (97.6%; 120/123 eyes; P = 0.102). However, the surgical time was significantly longer in group A (60.2 ± 17.1 min) than that in group B (46.9 ± 12.6 min) (P < 0.001). The multiple linear regression analysis revealed that surgical time was significantly correlated with using the wide-angle noncontact viewing system for vitreous shaving (adjusted R 2 = 0.248; beta [standard partial regression coefficient] = -0.447, P < 0.001), the number of retinal breaks (beta = 0.182, P = 0.001), and the quadrant of retinal detachment (beta = 0.205, P < 0.001).
CONCLUSION: The surgical outcomes were similar regardless of the shaving procedure performed, and the surgical time was shortened by using the wide-angle noncontact viewing system for vitreous shaving.

Introduction

Rhegmatogenous retinal detachment (RRD) is a serious retinal disorder that can lead to blindness. Pars plana vitrectomy (PPV) has been gaining popularity for the treatment of primary RRD since 2008.1,2 Several studies have reported an increase in the use of PPV for treating eyes with RRD.3–6 The Japan Retinal Detachment Registry revealed that in 2016 and 2017, vitrectomy was employed to treat 77.8% of RRD cases.7,8

The vitreous near the vitreous base was thought to be associated with the formation of retinal breaks, and in such cases peripheral vitreous shaving was performed to eliminate the traction of the vitreous to the retina.9–11 Two approaches can be used for vitreous shaving: an ocular indentation can be created to observe the periphery of the retina using either slit lamp microscope illumination or a wide-angle noncontact viewing system. Recently, Tabandeh et al reported the outcome of retinal detachment (RD) surgery without scleral-depressed shaving of the vitreous base.12 However, little is known regarding the extent of vitreous shaving that is appropriate in this context because no method is available to objectively quantify the residual vitreous.

To objectively observe the peripheral vitreous and retina, we developed a procedure using intraoperative optical coherence tomography (iOCT).13 We found that slit lamp microscope illumination resulted in enhanced vitreous shaving compared with the use of a wide-angle noncontact viewing system, possibly because of improved peripheral viewing.14 The purpose of this study was to examine the treatment results in response to different peripheral vitreous-shaving procedures for RRD.

Materials and Methods

This retrospective study was performed in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of the Yamagata University Faculty of Medicine (approval number: H26-21). All data were fully anonymized before we accessed them, and the institutional review board waived the requirement for informed consent. We conducted a retrospective analysis of 269 RRD eyes treated by a single surgeon (K Nishitsuka) between June 2015 and May 2020 using the following exclusion criteria for the proposed air tamponade selection: more than two weeks since onset, giant retinal tears, a history of complications following cataract surgery, high myopia, and proliferative vitreoretinopathy (PVR) classified as grade C or higher. The selected cases were treated using different vitreous-shaving procedures. Cases that were treated between June 2015 and April 2018 underwent shaving under slit lamp microscope illumination (Group A) whereas cases that were treated between May 2018 and May 2020 underwent shaving under a wide-angle viewing system (Group B).

Surgical Procedure of Vitrectomy for RRD Treatment

Retrobulbar anesthesia was administered using 6 mL of a mixture of 2% lidocaine and 0.5% levobupivacaine. We used the 25GPPV wide-angle noncontact viewing system (Resight®; Carl Zeiss Meditec AG, Jena, Germany) with the Constellation Vision System (Alcon Laboratories, Inc., Fort Worth, TX, USA) or the EVA vitrectomy system (DORC, Zuidland, The Netherlands). We created three cannulas with conjunctival displacement and oblique-angled sclerotomies in the inferotemporal, superotemporal, and superonasal quadrants 3.0 to 4.0 mm posterior to the limbus. Before performing the vitrectomy, all phakic eyes underwent phacoemulsification and intraocular lens implantation (PEA + IOL) with a sclerocorneal incision using the same machine. After core vitrectomy, the vitreous gel was visualized with an injection of triamcinolone acetonide (MaQaid, Wakamoto Pharmaceutical, Tokyo, Japan) during midperipheral vitrectomy. Vitreous shaving around the retinal break with ocular indentation was performed under slit lamp microscope illumination (Visulux; Zeiss, Oberkochen, Germany) in group A (Figure 1), and under a wide-angle noncontact viewing system using chandelier endoillumination (TotalView Chandelier; DORC, Zuidland, The Netherlands) in group B (Figure 2). The peripheral vitreous gel then underwent careful 360° shaving with scleral indentation. An internal drainage retinotomy was not performed. All RDs were restored intraoperatively. To completely surround all retinal breaks, we applied retinal photocoagulation after fluid-gas exchange. All sclerotomy sites were closed with 8–0 Vicryl sutures. All patients were treated by hospitalization and had a daily fundus examination after the surgery. We encouraged all patients to assume a prone position following surgery and to remain prone until the intraocular gas concentration was reduced in half. Subsequently, all patients were permitted to assume any position, except for the supine position, until the intraocular gas disappeared.

Figure 1

Vitreous shaving with ocular indentation under slit lamp microscope illumination.

Figure 2

Vitreous shaving with ocular indentation under a wide-angle noncontact viewing system using chandelier endoillumination.

Data Collection

The following patient demographic data were collected: age, sex, laterality of the eyes, time to surgery, number of retinal breaks, quadrant of RD, location of retinal breaks, lens status, macular status, procedure used to perform the vitreous shaving, surgical time, and primary success for RD.

Statistical Analyses

The statistical analyses were performed using Fisher’s exact test, the Chi-square test, and the Mann–Whitney U-test. We performed a multivariate linear regression analysis to identify potential factors that influence the differences of vitreous shaving results (P < 0.05 for selective criterion). For all analyses, P < 0.05 was statistically significant. All statistical data were analyzed using PASW Statistics 18 (SPSS Inc., Chicago, IL, USA).

Results

A total of 269 eyes were evaluated in this study, including 146 eyes in group A and 123 eyes in group B. Table 1 shows the patient characteristics and comparison of surgical outcomes between group A and group B. There were 47 women in group A and 33 in group B (P = 0.352). The mean ± standard deviation (SD) age was 63.3 ± 9.7 years in group A and 62.1 ± 10.5 years in group B (P = 0.278). There was a mean ± SD of 1.7 ± 1.1 retinal breaks in group A and 2.1 ± 1.4 in group B (P = 0.01). A total of 41 eyes (28.1%) in group A and 36 (29.3%) in group B displayed lower breaks (P = 0.893). The mean ± SD quadrant of RD was 1.7 ± 0.7 in group A and 1.9 ± 0.8 in group B (P = 0.016). A total of 68 eyes (46.6%) in group A and 72 (58.5%) in group B displayed macular detachment (P = 0.066). There were 118 phakic eyes (78.1%) in group A and 97 (78.9%) in group B (P = 1). The primary success rates were similar in group A (97.3%; 142/146 eyes) and group B (97.6%; 120/123 eyes; P = 0.102). However, the surgical time was significantly longer in group A (60.2 ± 17.1 min) than it was in group B (46.9 ± 12.6 min) (P < 0.001). No anterior PVR complication was seen in all the patients.

Table 1

Patient Demographics of Preoperative and Intraoperative Ophthalmologic Findings, and Comparison of Surgical Outcomes After RD Treatment Between Group A and Group B

	Group A N = 146	Group B N = 123	P value
Age	63.3 ± 9.7	62.1 ± 10.5	0.278
Sex (female)	47 (32.2%)	33 (26.8%)	0.352
Laterality (right)	89 (61.0%)	90 (73.2%)	0.038
Time to surgery (week)	1.269 ± 0.463	1.317 ± 0.484	0.448
Number of retinal breaks	1.7 ± 1.1	2.1 ± 1.4	0.01
Quadrant of RD	1.7 ± 0.7	1.9 ± 0.8	0.016
Lower retinal break	41 (28.1%)	36 (29.3%)	0.893
Macular status (macula off)	68 (46.6%)	72 (58.5%)	0.066
Lens status (phakia)	114 (78.1%)	97 (78.9%)	1
Surgical time (min)	60.2 ± 17.1	46.9 ± 12.6	<0.001
Surgical success	142 (97.3%)	120 (97.6%)	0.893

Notes: Group A: vitreous shaving was performed under slit lamp microscope illumination with an ocular indentation. Group B: vitreous shaving was performed under a wide-angle noncontact viewing system using chandelier endoillumination with an ocular indentation.

Abbreviation: RD, retinal detachment.

Table 2 shows the multiple regression analysis of the surgical time and clinical variables for all cases included in this study. A shortened surgical time was significantly correlated with shaving using the wide-angle noncontact viewing system (adjusted R = 0.248; beta [standard partial regression coefficient] = −0.447, P < 0.001). Moreover, the number of retinal breaks (beta = 0.182, P = 0.001) and the quadrant of RD (beta = 0.205, P < 0.001) were significantly correlated with an extended surgical time.

Table 2

Univariate and Multiple Regression Analysis of the Surgical Time and Clinical Variables in All Cases in This Study

Independent Variable	Univariate Analysis		Multivariate Analysis
	βa	P value	βa	P value
Age	−0.24	0.690
Sex (female)	0.19	0.753
Laterality (right)	−0.139	0.022	−0.92	0.088
Time to surgery	0.019	0.762
Number of retinal breaks	0.124	0.042	0.182	0.001
Quadrant of RD	0.161	0.008	0.205	<0.001
Lower retinal break	0.093	0.127
Macular status (macula off)	0.079	0.196
Lens status (phakia)	0.102	0.095
Shaving with the wide-angle noncontact viewing system	−0.401	<0.001	−0.447	<0.001

Notes: Adjusted R2 = 0.248 for the surgical time in the multiple linear regression analysis (P < 0.05). aStandard partial regression coefficient.

Abbreviation: RD, retinal detachment.

Discussion

Routine prophylactic, scleral-depressed shaving of the vitreous base has been advocated by many as part of PPV for primary RRD.10 Our previous study, which quantified the peripheral vitreous using iOCT, showed that the amount of residual vitreous differed according to the different shaving techniques used (slit lamp microscope illumination vs wide-angle noncontact viewing system). Shaving under slit lamp microscope illumination enabled the reduction of the more peripheral vitreous. Furthermore, slit lamp observation allowed a clearer focus on the peripheral vitreous than did the wide-angle noncontact viewing system. Additionally, shaving under slit lamp microscope illumination required a greater degree of indentation than did the wide-angle noncontact viewing system. The combination with the slit lamp allowed clear visualization of the peripheral vitreous.15 These aspects may explain the greater time required for surgery in group A (Table 1). Conversely, the wide-angle noncontact viewing system requires a lower degree of indentation to observe the peripheral part of the retina. This is advantageous for microincision vitrectomy surgery (MIVS) because the conjunctiva is preserved during this procedure, which hampers strong indentation. In this study, the surgical time was shorter in group B, in which the vitreous was shaved under the wide-angle noncontact viewing system (Table 1).

In turn, greater shaving of the peripheral vitreous might prevent the formation of a scaffold by the vitreous base and the subsequent development of future anterior PVR and contraction, which leads to new retinal tears and subsequent RD. However, in the present study, the primary success rate did not differ between groups A and B despite the different amounts of residual vitreous (Table 1). Thus, the therapeutic effect and the amount of vitreous shaving might not be proportional. A recent study of vitreous shaving without scleral indentation in RRD suggested that a sufficient effect can be obtained if appropriate vitreous shaving is performed.12 When performing vitreous shaving without scleral indentation, we believe that it is important to verify the amount of shaved vitreous to evaluate the optimum vitrectomy shaving. The use of iOCT for the peripheral vitreous and retina might be helpful for performing such a study objectively.13,14,16

The procedures in this study were all performed by the same surgeon, which eliminates the presence of surgeon bias. The use of a wide-angle noncontact viewing system, the number of retinal breaks, and the quadrant of RD were identified as independent factors related to surgery time, and the results were extremely reasonable. The current study showed that there was no difference in the primary success rate between using the wide-angle noncontact viewing system and slit lamp illumination. In this study, vitreous shaving was performed at not only retinal breaks but also at 360-degrees near the vitreous base in all patients. Our previous study showed that iOCT could detect retinal breaks that occur near the peripheral posterior vitreous detachment and vitreous base.14 We named this site the “vitreo-retinal angle” based on the findings of iOCT.13,14,16 Retinal breaks may occur when the vitreous near the vitreo-retinal angle causes peripheral posterior vitreous detachment. Thus, 360-degree vitreous shaving may be effective in preventing new postoperative retinal breaks.

Treatment outcomes for RRD vary depending on complexity.17–23 In this study, the subjects had relatively uncomplicated RRD, and the treatment was performed to reduce the effect of the severity of the RRD pathology. In complicated RD, the vitreous base may form a scaffold for the development of future anterior PVR.1,2,10,24 However, there is little evidence in the literature supporting this clinical impression.12 Moreover, there is still no clear evidence of a difference in treatment outcomes between shaving only at the retinal breaks and 360-degree shaving. However, this study provides evidence that the peripheral shaving procedure did not affect RRD treatment outcomes and development of anterior PVR, at least for uncomplicated RRD. Future studies must focus on complicated RD and make comparisons based on more detailed differences in surgical techniques.

This study has several limitations. Given the retrospective nature of the present study, some items, including the location of the retinal break, quadrants of RD, lens status, and macular status, differed between groups A and B. The results of this study stem from a single surgeon, with no bias caused by the skill of the surgeon; however, the results may differ if this type of surgery is performed by different surgeons. Due to the surgical data from single surgeon, increased experience may affect surgical time. Future prospective studies based on the results of the present research should provide further validation of the effectiveness of vitreous shaving.

In summary, we compared surgical outcomes for RRD between the different peripheral vitreous-shaving techniques performed. We found no differences in the therapeutic effects exhibited by shaving using slit lamp microscope illumination or a wide-angle noncontact viewing system. The pathology of RRD, including the number of retinal breaks and quadrant of RD, prolonged the surgical time, and the use of a wide-angle noncontact viewing system shortened the surgical time required. Future prospective studies should be conducted to establish an appropriate procedure for vitreous shaving.