Hongmin Li1,2, Suliman Khan1,2, Rabeea Siddique1,2, Qian Bai1,2, Yang Liu1,2, Ruiyi Zhang1,2, Yan Zhang1,2, V Wee Yong3, Mengzhou Xue1,2. 1. The Departments of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University. 2. Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, Henan, China. 3. Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Abstract
Objectives: This article aimed to analyze the relationship between obesity and the efficacy of acute ischaemic stroke patients treated with IVT.Background: Stroke causes morbidity and mortality in large numbers of individuals annually. Intravenous thrombolysis (IVT)with recombinant tissue plasminogen activator (r-tPA) is currently the only approved by the FDA for treatment of acute ischaemic stroke. Researchers have focused on studying the mechanisms associated with ischaemic stroke. Obesity is an established vascular risk factor with increasing prevalence and a huge impact on public health worldwide. It is an independent predictor for ischaemic stroke with a 4% risk increase for each unit augmentation in body mass index (BMI). Therefore, obese patients will constitute an increasing subgroup of candidates for IVT. However, its impact on prognosis in acute ischaemic stroke patients with intravenous thrombolysis did not reach a consensus conclusion. Methods: Systematic literature search of PUBMED databases published before August 2020, was performed to identify studies addressing the role of obesity in acute ischaemic stroke patients treated with IVT. Studies included randomized clinical trials, observational studies, guideline statements, and review articles.Conclusions: Obesity may be related to long-term prognosis of large group of AIS patients treated with IVT. It depends on the scale of clinical study samples, follow-up time, and evaluation criteria.
Objectives: This article aimed to analyze the relationship between obesity and the efficacy of acute ischaemic strokepatients treated with IVT.Background: Stroke causes morbidity and mortality in large numbers of individuals annually. Intravenous thrombolysis (IVT)with recombinant tissue plasminogen activator (r-tPA) is currently the only approved by the FDA for treatment of acute ischaemic stroke. Researchers have focused on studying the mechanisms associated with ischaemic stroke. Obesity is an established vascular risk factor with increasing prevalence and a huge impact on public health worldwide. It is an independent predictor for ischaemic stroke with a 4% risk increase for each unit augmentation in body mass index (BMI). Therefore, obesepatients will constitute an increasing subgroup of candidates for IVT. However, its impact on prognosis in acute ischaemic strokepatients with intravenous thrombolysis did not reach a consensus conclusion. Methods: Systematic literature search of PUBMED databases published before August 2020, was performed to identify studies addressing the role of obesity in acute ischaemic strokepatients treated with IVT. Studies included randomized clinical trials, observational studies, guideline statements, and review articles.Conclusions: Obesity may be related to long-term prognosis of large group of AISpatients treated with IVT. It depends on the scale of clinical study samples, follow-up time, and evaluation criteria.
Entities:
Keywords:
Ischaemic stroke; body mass index; intravenous thrombolysis; obesity