Literature DB >> 34108618

The role of polyamines in gastric cancer.

Kara M McNamara1,2, Alain P Gobert1,3, Keith T Wilson4,5,6,7,8.   

Abstract

Advancements in our understanding of polyamine molecular and cellular functions have led to increased interest in targeting polyamine metabolism for anticancer therapeutic benefits. The polyamines putrescine, spermidine, and spermine are polycationic alkylamines commonly found in all living cells and are essential for cellular growth and survival. This review summarizes the existing research on polyamine metabolism and function, specifically the role of polyamines in gastric immune cell and epithelial cell function. Polyamines have been implicated in a multitude of cancers, but in this review, we focus on the role of polyamine dysregulation in the context of Helicobacter pylori-induced gastritis and subsequent progression to gastric cancer. Due to the emerging implication of polyamines in cancer development, there is an increasing number of promising clinical trials using agents to target the polyamine metabolic pathway for potential chemoprevention and anticancer therapy.

Entities:  

Mesh：

Substances：

Year:  2021        PMID： 34108618      PMCID： PMC8262120          DOI： 10.1038/s41388-021-01862-x

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  113 in total

1.  Identification of differentially expressed genes in normal and tumor human gastric tissue.

Authors:  M H Jung; S C Kim; G A Jeon; S H Kim; Y Kim; K S Choi; S I Park; M K Joe; K Kimm
Journal:  Genomics       Date:  2000-11-01       Impact factor: 5.736

2.  Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme.

Authors:  Jong-Hwan Park; L Aravind; Edith C Wolff; Jörn Kaevel; Yeon Sook Kim; Myung Hee Park
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-21       Impact factor: 11.205

Review 3.  Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer.

Authors:  Shima Nakanishi; John L Cleveland
Journal:  Amino Acids       Date:  2016-06-29       Impact factor: 3.520

Review 4.  Pathology of gastric intestinal metaplasia: clinical implications.

Authors:  Pelayo Correa; M Blanca Piazuelo; Keith T Wilson
Journal:  Am J Gastroenterol       Date:  2010-03       Impact factor: 10.864

5.  Helicobacter pylori infection and the development of gastric cancer.

Authors:  N Uemura; S Okamoto; S Yamamoto; N Matsumura; S Yamaguchi; M Yamakido; K Taniyama; N Sasaki; R J Schlemper
Journal:  N Engl J Med       Date:  2001-09-13       Impact factor: 91.245

6.  Hypusine formation in protein by a two-step process in cell lysates.

Authors:  R J Murphey; E W Gerner
Journal:  J Biol Chem       Date:  1987-11-05       Impact factor: 5.157

7.  Increase in apoptosis and decrease in ornithine decarboxylase activity of the gastric mucosa in patients with atrophic gastritis and gastric ulcer after successful eradication of Helicobacter pylori.

Authors:  R Hirasawa; M Tatsuta; H Iishi; H Yano; M Baba; N Uedo; N Sakai
Journal:  Am J Gastroenterol       Date:  1999-09       Impact factor: 10.864

8.  Polyamine depletion therapy in prostate cancer.

Authors:  B H Devens; R S Weeks; M R Burns; C L Carlson; M K Brawer
Journal:  Prostate Cancer Prostatic Dis       Date:  2000-12       Impact factor: 5.554

9.  Merging perspectives: genotype-directed molecular therapy for hereditary diffuse gastric cancer (HDGC) and E-cadherin-EGFR crosstalk.

Authors:  Dandan Li; Winifred Lo; Udo Rudloff
Journal:  Clin Transl Med       Date:  2018-02-22

Review 10.  Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases.

Authors:  Nicole LoGiudice; Linh Le; Irene Abuan; Yvette Leizorek; Sigrid C Roberts
Journal:  Med Sci (Basel)       Date:  2018-02-08
View more
  5 in total

1.  Ornithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection.

Authors:  Yvonne L Latour; Johanna C Sierra; Kara M McNamara; Thaddeus M Smith; Paula B Luis; Claus Schneider; Alberto G Delgado; Daniel P Barry; Margaret M Allaman; M Wade Calcutt; Kevin L Schey; M Blanca Piazuelo; Alain P Gobert; Keith T Wilson
Journal:  J Immunol       Date:  2022-07-27       Impact factor: 5.426

Review 2.  Polyamines in cancer: integrating organismal metabolism and antitumour immunity.

Authors:  Cassandra E Holbert; Michael T Cullen; Robert A Casero; Tracy Murray Stewart
Journal:  Nat Rev Cancer       Date:  2022-04-27       Impact factor: 69.800

Review 3.  Polyamine Metabolism in Leishmania Parasites: A Promising Therapeutic Target.

Authors:  Nicola S Carter; Yumena Kawasaki; Surbhi S Nahata; Samira Elikaee; Sara Rajab; Leena Salam; Mohammed Y Alabdulal; Kelli K Broessel; Forogh Foroghi; Alyaa Abbas; Reyhaneh Poormohamadian; Sigrid C Roberts
Journal:  Med Sci (Basel)       Date:  2022-04-22

4.  Specific and sensitive GC-MS analysis of hypusine, Nε-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study.

Authors:  Svetlana Baskal; Annette Kaiser; Catharina Mels; Ruan Kruger; Dimitrios Tsikas
Journal:  Amino Acids       Date:  2022-03-03       Impact factor: 3.789

5.  Nanospermidine in Combination with Nanofenretinide Induces Cell Death in Neuroblastoma Cell Lines.

Authors:  Pietro Lodeserto; Martina Rossi; Paolo Blasi; Giovanna Farruggia; Isabella Orienti
Journal:  Pharmaceutics       Date:  2022-06-07       Impact factor: 6.525
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.